Asian Journal of Research in Chemistry

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Development and Validation of RP-HPLC Method for Simultaneous Estimation of Naproxen and Esomeprazole in Pharmaceutical Dosage Form


Affiliations
1 Department of Pharmaceutical Analysis, PNR College of Pharmacy, Shamshabad, RR Dt., Telangana, India
2 Department of Pharmaceutical Chemistry, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak Dt, Telangana, India
     

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The objective of the study was to develop a simple, accurate, precise RP-HPLC method for the determination of Esomeprazole and Naproxen using mobile phase (A mixture of Acetonitrile and Methanol in the ratio of 60:40 was considered to be the optimal composition of solvent) as the solvent. The proposed method was involves the measurement of retention time at selected analytical wavelength 260.0 nm was selected as the analytical wavelength. The retention time of Esomeprazole and Naproxen was found to be 3.425 and 4.352. The linearity of the proposed method was in the range of r = 0.9999 for Esomeprazole and r = 0.9999 for Naproxen. The method was statistically validated for its linearity, accuracy and precision of the formulation.

Keywords

Esomeprazole, Naproxen, RP-HPLC Method.
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  • Development and Validation of RP-HPLC Method for Simultaneous Estimation of Naproxen and Esomeprazole in Pharmaceutical Dosage Form

Abstract Views: 267  |  PDF Views: 0

Authors

Haritha Gali
Department of Pharmaceutical Analysis, PNR College of Pharmacy, Shamshabad, RR Dt., Telangana, India
Vishwanadham Yerragunta
Department of Pharmaceutical Chemistry, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak Dt, Telangana, India

Abstract


The objective of the study was to develop a simple, accurate, precise RP-HPLC method for the determination of Esomeprazole and Naproxen using mobile phase (A mixture of Acetonitrile and Methanol in the ratio of 60:40 was considered to be the optimal composition of solvent) as the solvent. The proposed method was involves the measurement of retention time at selected analytical wavelength 260.0 nm was selected as the analytical wavelength. The retention time of Esomeprazole and Naproxen was found to be 3.425 and 4.352. The linearity of the proposed method was in the range of r = 0.9999 for Esomeprazole and r = 0.9999 for Naproxen. The method was statistically validated for its linearity, accuracy and precision of the formulation.

Keywords


Esomeprazole, Naproxen, RP-HPLC Method.