Synthesis and Pharmacology of Some Aryloxypropanolamine Derivatives

4-hydroxy-3-methoxy benzaldehyde on reaction with substituted anilines gave imine compounds (2a-d) which on reaction with epichlorhydrin gave epoxides (3a-d). These compounds on reaction with amines gave 1-(2-methoxy-4-arylimino phenoxy)-3-(substituted amino)-propan-2-ol (4a-h). All newly synthesized compounds were characterized on the basis of spectral analysis and evaluated for β-blocking activity. Compound (4e) was found to be most potent compound of this series and was compared with the reference drug, propranolol. Other compounds in this series were found to possess varied degree of β-blocking activity.