Synthesis, Characterization of 3-chloro 4-(4- Substituted Phenyl -1- (4- Nitro Phenylazetidin -2-one by Microwave Method and Evaluation of their Antibacterial Activity

Non classical, High-speed, environmentally benign synthesis with microwaves has attracted researchers for organic synthesis was a considerable amount of attention in recent years. An expeditious one pot microwave irradiation method for preparation of 2- azetidinones is developed. This method has been assessed as greener methodology. In our present study, A series of six novel 2-azetidinones were synthesized, compounds were identified by melting point and thin layer chromatography , functional groups of synthesized compounds were confirmed by IR spectroscopy, compounds were evaluated for their antimicrobial activities. The activities were due to cyclic carbonyl group in 2-azetidinones. Some of the compounds have shown comparative antimicrobial activities against all the microbial strains.