Application of Oxidants to the Spectrophotometric Determination of Cephalosporins (Cefditoren Pivoxil and Cefdinir) In Formulations

Three new spectrophotometric methods (A, B and C) for the determination of Cephalosporins (Cefditoren Pivoxil and Cefdinir) have been proposed. These methods are based on the oxidation of the drug with Fe (III) and the estimation of Fe (II) produced after chelation with either 1,10- Phenanthroline or 2,2’-Bipyridyl or Potassium Ferricyanide at 510, 525, 730 nm (for Cefditoren Pivoxil) and at 512, 510, 700 nm (for Cefdinir). The Beer’s law was obeyed in the concentration range of 4-20, 4-20, 2-10 μg/ml (for Cefditoren Pivoxil) and 2-8, 8-24, 4-12μg/ml (for Cefdinir) for methods A, B and C respectively. Thus results of the proposed methods were validated statistically and applied successfully to the determination of Cefditoren Pivoxil and Cefdinir in bulk and its pharmaceutical formulations without any interference from excipients.