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Synthesis and Antibacterial Study of Some New Schiff's Bases of 2- Hydrazinyl-1-(1H-Imidazole-1-yl)-Ethanone
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Imidazole on reaction with chloroacetyl chloride afford 2-chloro-1-(1H-imidazole-1-yl)-ethanone, 1 which on treatment with hydrazine hydrate has yielded 2-hydrazinyl-1-(1H-imidazol-1-yl)-ethanone, 2. Condensation of 2 with various aromatic aldehydes afforded sustituted Schiff’s base of 2-hydrazinyl-1-(1H-imidazol-1-yl)-ethanone. The structures of all the products were characterized on the basis of their IR, Mass and 1H-NMR spectroscopic data analysis. All the synthesised products were screened for their antibacterial activity against gram-positive and gram negative bacteria by cup-plate method.
Keywords
Synthesis, Imidazole, Aromatic Aldehydes, Schiff’s Bases, Antibacterial Activity.
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