Asian Journal of Research in Chemistry

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Gold–Nanoparticles A Novel Nano-Photosensitizer for Photodynamic Therapy


Affiliations
1 Department of Chemistry, Queen Mary’s College, Chennai, India
2 Department of Physics, Anna University, Chennai, India
3 Department of Chemistry, Adhiparasakthi College of Science, Kalavai, India
     

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Gold Nanoparticles (GNPs) of size below 5 nm were prepared by reduction of Chloroauric acid using sodium citrate and NaBH4 and characterized. High resolution transmission electron microscopic measurements revealed their size less than 5nm. Their photodynamic action was tested in human erythrocytes. The percent hemolysis showed a decrease in PDA above a particular GNPs concentration. The study of the effect of scavengers GSH and NaN3 showed formation of a considerable amount of superoxide anion and singlet oxygen that caused cell death. The detailed mechanism is discussed. GNPs being nontoxic serve as proper substitute for the conventional photosensitizers such as organic dyes.


Keywords

Photodynamic Therapy, Photodynamic Activity, Gold Nanoparticles, Reactive Oxygen Species.
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  • Gold–Nanoparticles A Novel Nano-Photosensitizer for Photodynamic Therapy

Abstract Views: 261  |  PDF Views: 1

Authors

Karunakaran Sulochana Meena
Department of Chemistry, Queen Mary’s College, Chennai, India
Thyagarajan Venkataraman
Department of Physics, Anna University, Chennai, India
Singaravel Ganesan
Department of Chemistry, Adhiparasakthi College of Science, Kalavai, India
Prakasa Rao Aruna
Department of Chemistry, Adhiparasakthi College of Science, Kalavai, India

Abstract


Gold Nanoparticles (GNPs) of size below 5 nm were prepared by reduction of Chloroauric acid using sodium citrate and NaBH4 and characterized. High resolution transmission electron microscopic measurements revealed their size less than 5nm. Their photodynamic action was tested in human erythrocytes. The percent hemolysis showed a decrease in PDA above a particular GNPs concentration. The study of the effect of scavengers GSH and NaN3 showed formation of a considerable amount of superoxide anion and singlet oxygen that caused cell death. The detailed mechanism is discussed. GNPs being nontoxic serve as proper substitute for the conventional photosensitizers such as organic dyes.


Keywords


Photodynamic Therapy, Photodynamic Activity, Gold Nanoparticles, Reactive Oxygen Species.