Simultaneous Estimation of Montelukast Sodium and Levocetrizine Hydrochloride by UV-Visible Spectrometry

Two methods for simultaneous estimation of Montelukast sodium and Levocetrizine HCl in two component solid dosage forms have been developed. The methods employ the application of absorption corrected for interference, the first order derivative method. All these methods utilize methanol as a solvent. In absorption corrected for interference method montelukast sodium shows maximum absorption at a wavelength of 280.2 nm ,and levocetrizine HCl at 232.2 nm, where the linearity ranges for both the drugs were 5-30 μg/ml. At the wavelength of montelukast sodium levocetrizine HCl shows zero absorbance but at the wavelength of levocetrizine HCl, montelukast sodium shows some absorbance from this method the amount of montelukast sodium were determined at 280.2 nm, while at the wavelength of levocetrizine HCl we get the total absorption of both the drug, the amount of levocetrizine HCl were determined by applying the absorption corrected for interference method. In First order derivative method, the absorbance values at 270.8 nm and 224 nm of first derivative spectrum was used for the estimation of montelukast sodium and levocetrizine HCl respectively without mutual interference. This method obeyed Beers law in the concentration range of 10-60 μg / ml for montelukast sodium and 10-35 μg / ml for levocetrizine HCl, the results of analysis of both method have been validated statistically and recovery studies confirmed the accuracy of the proposed method.