Asian Journal of Research in Chemistry

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Synthesis and Pharmacological Screening of Some New Benzimidazole Derivatives


Affiliations
1 Tallapadmavathi College of Pharmacy, Urus, Kareemabad, Warangal, A.P, India
2 Trinity College of Pharmaceutical Sciences, Peddapalli, Karimnagar, A.P, India
3 Balaji Institute of Pharmaceutical Sciences, Narsampet, Warangal, A.P, India
     

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Seven different 2-[(1H-benzimidazol-2yl methyl) sulfanyl)] –N4-(phenylmethylidene) acetohydrazides were synthesized from 2-[(1H- benzimidazol-2-yl methyl) sulfanyl] acetohydrazide on reaction with different aromatic aldehydes in methanol. Each of these compounds were purified and characterized by their spectral data. All the compounds were assayed for their anti-inflammatory activity by carrageenan induced rat hind paw edema method. Some of these compounds showed moderate to considerable anti-inflammatory activity.


Keywords

Benzimidazol-2-methane Thiol Derivatives, Aromatic Aldehydes, Anti-Inflammatory Activity.
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  • Synthesis and Pharmacological Screening of Some New Benzimidazole Derivatives

Abstract Views: 259  |  PDF Views: 1

Authors

S. Manjula
Tallapadmavathi College of Pharmacy, Urus, Kareemabad, Warangal, A.P, India
M. Aruna Devi
Trinity College of Pharmaceutical Sciences, Peddapalli, Karimnagar, A.P, India
N. Raghunandhan
Balaji Institute of Pharmaceutical Sciences, Narsampet, Warangal, A.P, India
J. Venkateshwar Rao
Tallapadmavathi College of Pharmacy, Urus, Kareemabad, Warangal, A.P, India

Abstract


Seven different 2-[(1H-benzimidazol-2yl methyl) sulfanyl)] –N4-(phenylmethylidene) acetohydrazides were synthesized from 2-[(1H- benzimidazol-2-yl methyl) sulfanyl] acetohydrazide on reaction with different aromatic aldehydes in methanol. Each of these compounds were purified and characterized by their spectral data. All the compounds were assayed for their anti-inflammatory activity by carrageenan induced rat hind paw edema method. Some of these compounds showed moderate to considerable anti-inflammatory activity.


Keywords


Benzimidazol-2-methane Thiol Derivatives, Aromatic Aldehydes, Anti-Inflammatory Activity.