Asian Journal of Research in Chemistry

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New UV-Visible Spectrophotometric Methods for the Determination of Tadalafil in Bulk and Pharmaceutical Formulation


Affiliations
1 Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
     

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A simple, sensitive and reproducible UV-Visible spectrophotometric methods (Method A to Method C) are developed for the determination of Tadalafil (TADL) in pure and dosage forms. Method A is based on the formation of colored species on treatment of Tadalafil (TADL) with Folin-Ciocalteu reagent in presence of 4% NaOH Solution. Method B is based on the formation of colored species on treatment of Tadalafil (TADL) with Sodium nitroprusside and Hydroxyl amine. Method C represents UV Spectrophotometric determination of Tadalafil (TADL) and its dosage forms in pH 2.9 Buffer:Acetonitrile (40:60v/v) at 285nm.
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  • New UV-Visible Spectrophotometric Methods for the Determination of Tadalafil in Bulk and Pharmaceutical Formulation

Abstract Views: 208  |  PDF Views: 1

Authors

G. V. H. Raju
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
S. Ganapathy
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
D. G. Sankar
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
P. Y. Naidu
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India

Abstract


A simple, sensitive and reproducible UV-Visible spectrophotometric methods (Method A to Method C) are developed for the determination of Tadalafil (TADL) in pure and dosage forms. Method A is based on the formation of colored species on treatment of Tadalafil (TADL) with Folin-Ciocalteu reagent in presence of 4% NaOH Solution. Method B is based on the formation of colored species on treatment of Tadalafil (TADL) with Sodium nitroprusside and Hydroxyl amine. Method C represents UV Spectrophotometric determination of Tadalafil (TADL) and its dosage forms in pH 2.9 Buffer:Acetonitrile (40:60v/v) at 285nm.