Asian Journal of Research in Chemistry

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Synthesis and Cytotoxic Activity of New Indole Derivatives


Affiliations
1 Talla Padmavathi College of Pharmacy, Orus, Warangal-506009, A.P, India
2 University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, A.P, India
     

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Some new (Napthalen-1-yloxyl/2-yloxy)-acetic acid (2-oxo-1, 2-dihydro-indole-3-ylidene)-hydrazides (4 and 5) have been synthesized by condensing naphthyl-1-oxy/2-oxy acetic acid hydrazides with different isatins. Their chemical structures have been confirmed by IR, NMR, and Mass spectroscopy and by elemental analysis. Investigation of cytotoxic activity was done by MTT assay method using HeLa and MCF cell lines. The compounds with 6-Bromo substitution (4e, 5e) have shown the prominent cytotoxic activity among the synthesized compounds.

Keywords

Synthesis/Indoles/Cytotoxicity.
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  • Synthesis and Cytotoxic Activity of New Indole Derivatives

Abstract Views: 241  |  PDF Views: 1

Authors

C. Radhika
Talla Padmavathi College of Pharmacy, Orus, Warangal-506009, A.P, India
Venkatesham Akena
University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, A.P, India
J. Venkateshwar Rao
Talla Padmavathi College of Pharmacy, Orus, Warangal-506009, A.P, India
M. Sarangapani
University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, A.P, India

Abstract


Some new (Napthalen-1-yloxyl/2-yloxy)-acetic acid (2-oxo-1, 2-dihydro-indole-3-ylidene)-hydrazides (4 and 5) have been synthesized by condensing naphthyl-1-oxy/2-oxy acetic acid hydrazides with different isatins. Their chemical structures have been confirmed by IR, NMR, and Mass spectroscopy and by elemental analysis. Investigation of cytotoxic activity was done by MTT assay method using HeLa and MCF cell lines. The compounds with 6-Bromo substitution (4e, 5e) have shown the prominent cytotoxic activity among the synthesized compounds.

Keywords


Synthesis/Indoles/Cytotoxicity.