Asian Journal of Research in Chemistry

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Synthesis, Characterization and Pharmacological Evaluation of Novel Spiro Heterocyclic Compounds as Anti Diabetic Agents


Affiliations
1 Department of Chemistry, CMJ University, Shillong-793101, India
     

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Natural products possessing a spiro carbon in their molecules have proven their biological activity in agriculture and medicine. The present paper describes the synthesis, characterization of five newly synthesized Spiro-compounds characterized by means of chromatography, IR, 1H-NMR and Mass spectral analysis. The author carried in vitro anti diabetic methods like alpha amylase and alpha glucosidase methods for anti diabetic activity of tilted compounds. The investigation of anti diabetic activity revealed that the test compounds of Spiro compounds showed favorable anti diabetic activity. Among the titled compounds some were having potent antidiabetic activity.

Keywords

Spiro Heterocyclic Compounds, Spectral Analysis, In Vitro Antidiabetic Activity, Alpha Amylase Enzyme Method and Alpha-Glucosidase Enzyme Method.
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  • Synthesis, Characterization and Pharmacological Evaluation of Novel Spiro Heterocyclic Compounds as Anti Diabetic Agents

Abstract Views: 544  |  PDF Views: 6

Authors

K. Kishore Kumar
Department of Chemistry, CMJ University, Shillong-793101, India
R. S. K. Sharma
Department of Chemistry, CMJ University, Shillong-793101, India
P. Chanti Babu
Department of Chemistry, CMJ University, Shillong-793101, India
M. Sreenivasa Rao
Department of Chemistry, CMJ University, Shillong-793101, India
K. Durga Prasadu
Department of Chemistry, CMJ University, Shillong-793101, India
D. Ravi Kumar
Department of Chemistry, CMJ University, Shillong-793101, India

Abstract


Natural products possessing a spiro carbon in their molecules have proven their biological activity in agriculture and medicine. The present paper describes the synthesis, characterization of five newly synthesized Spiro-compounds characterized by means of chromatography, IR, 1H-NMR and Mass spectral analysis. The author carried in vitro anti diabetic methods like alpha amylase and alpha glucosidase methods for anti diabetic activity of tilted compounds. The investigation of anti diabetic activity revealed that the test compounds of Spiro compounds showed favorable anti diabetic activity. Among the titled compounds some were having potent antidiabetic activity.

Keywords


Spiro Heterocyclic Compounds, Spectral Analysis, In Vitro Antidiabetic Activity, Alpha Amylase Enzyme Method and Alpha-Glucosidase Enzyme Method.