Asian Journal of Research in Chemistry

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4-Thiazolidinones as Calcium Antagonist:Synthesis and Pharmacological Screening


Affiliations
1 Fisher BioPharma Services (India) Pvt. Ltd, "PHARMEZ" SEZ, Plot No 22, Matoda, National Highway 8A, Ahmedabad-382213, Gujarat, India
2 K.L.E.S’s College of Pharmacy, JNMC Campus, Belgaum-590010, Karnataka, India
     

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Various derivatives of 4-thaizolidinones were synthesized by reacting Schiff bases with thioglycollic acid. These alcoholic groups were further oxidized to get the carboxylic acid derivatives. The compounds were purified using flash chromatography and were characterized by physical, chemical and elemental analysis. The compounds were screened for calcium antagonistic activity on albino rats by using Biopack data acquisition system. Some compounds showed comparable activity with standard drug Diltiazem.

Keywords

4-Thiazolidinones, Calcium Antagonist, Calcium Channel Blockers, Schiff Bases.
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  • 4-Thiazolidinones as Calcium Antagonist:Synthesis and Pharmacological Screening

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Authors

K. Vaghela Gayatri
Fisher BioPharma Services (India) Pvt. Ltd, "PHARMEZ" SEZ, Plot No 22, Matoda, National Highway 8A, Ahmedabad-382213, Gujarat, India
S. B. Patil
K.L.E.S’s College of Pharmacy, JNMC Campus, Belgaum-590010, Karnataka, India
M. S. Palled
K.L.E.S’s College of Pharmacy, JNMC Campus, Belgaum-590010, Karnataka, India
A. R. Bhat
K.L.E.S’s College of Pharmacy, JNMC Campus, Belgaum-590010, Karnataka, India

Abstract


Various derivatives of 4-thaizolidinones were synthesized by reacting Schiff bases with thioglycollic acid. These alcoholic groups were further oxidized to get the carboxylic acid derivatives. The compounds were purified using flash chromatography and were characterized by physical, chemical and elemental analysis. The compounds were screened for calcium antagonistic activity on albino rats by using Biopack data acquisition system. Some compounds showed comparable activity with standard drug Diltiazem.

Keywords


4-Thiazolidinones, Calcium Antagonist, Calcium Channel Blockers, Schiff Bases.