Asian Journal of Research in Chemistry

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Spectrophotometric Estimation of Tramadol Hydrochloride in Bulk and Tablet Dosage Form


Affiliations
1 Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Jalgaon Dist, India
     

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A simple, sensitive, accurate and precise UV Spectrophotometric method has been developed for quantitative determination of Tramadol Hydrochloride in bulk and tablet formulations. The UV-spectrum was scanned between 220 to 400 nm and 270.5 nm was selected as maximum wavelength for absorption. Tramadol shows molar absorptivity of 1.771×104 l/mol/cm and Sandell’s sensitivity 0.16927 mcg/Sq.cm/0.001-absorbance units. Beer’s law was obeyed in the concentration range of 15-170 μg/ml. Results of analysis were validated statistically and by recovery studies.

Keywords

Tramadol Hydrochloride, Tablet, Ultraviolet Spectrophotometric Estimation.
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  • Spectrophotometric Estimation of Tramadol Hydrochloride in Bulk and Tablet Dosage Form

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Authors

S. R. Bavaskar
Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Jalgaon Dist, India
A. D. Agrawal
Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Jalgaon Dist, India
Y. S. Agrawal
Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Jalgaon Dist, India
A. N. Amrutkar
Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Jalgaon Dist, India
Niraj L. Badhe
Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Jalgaon Dist, India
P. S. Kawatikwar
Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Jalgaon Dist, India

Abstract


A simple, sensitive, accurate and precise UV Spectrophotometric method has been developed for quantitative determination of Tramadol Hydrochloride in bulk and tablet formulations. The UV-spectrum was scanned between 220 to 400 nm and 270.5 nm was selected as maximum wavelength for absorption. Tramadol shows molar absorptivity of 1.771×104 l/mol/cm and Sandell’s sensitivity 0.16927 mcg/Sq.cm/0.001-absorbance units. Beer’s law was obeyed in the concentration range of 15-170 μg/ml. Results of analysis were validated statistically and by recovery studies.

Keywords


Tramadol Hydrochloride, Tablet, Ultraviolet Spectrophotometric Estimation.