Asian Journal of Research in Chemistry

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Development and Validation of UV Spectrophotometric Methods of Loratadine in Bulk and Pharmaceutical Formulation


Affiliations
1 Dept. of Pharmaceutical Analysis, Vels University, P.V. Vaithiyalingam Road, Allavaram, Chennai-600117, India
     

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A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of loratadine in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 245 nm. The percentage recovery of loratadine is 99% ranged from (99.97±0.3969) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 5-30 μg/ml having line equation y=0.0043x+0.01 with correlation coefficient of 0.99868. Results of the analysis were validated statistically and by recovery study.

Keywords

UV Spectrophotometry, Loratadine.
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  • Development and Validation of UV Spectrophotometric Methods of Loratadine in Bulk and Pharmaceutical Formulation

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Authors

N. Harikrishnan
Dept. of Pharmaceutical Analysis, Vels University, P.V. Vaithiyalingam Road, Allavaram, Chennai-600117, India
R. Deepthi
Dept. of Pharmaceutical Analysis, Vels University, P.V. Vaithiyalingam Road, Allavaram, Chennai-600117, India
V. Manjusha
Dept. of Pharmaceutical Analysis, Vels University, P.V. Vaithiyalingam Road, Allavaram, Chennai-600117, India
P. Satya Vani
Dept. of Pharmaceutical Analysis, Vels University, P.V. Vaithiyalingam Road, Allavaram, Chennai-600117, India
M. V. Asha Jyothi
Dept. of Pharmaceutical Analysis, Vels University, P.V. Vaithiyalingam Road, Allavaram, Chennai-600117, India
C. Roosewelt
Dept. of Pharmaceutical Analysis, Vels University, P.V. Vaithiyalingam Road, Allavaram, Chennai-600117, India

Abstract


A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of loratadine in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 245 nm. The percentage recovery of loratadine is 99% ranged from (99.97±0.3969) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 5-30 μg/ml having line equation y=0.0043x+0.01 with correlation coefficient of 0.99868. Results of the analysis were validated statistically and by recovery study.

Keywords


UV Spectrophotometry, Loratadine.