Simultaneous Estimation of Mebendazole and Pyrental Pamoate by Absorption Ratio Method

Simple, sensitive and specific spectrophotometric method was developed and validated for quantitation of Mebendazole (MEB) and Pyrental Pamoate (PYR) in tablet dosage form. The new analytical method was developed based on the simultaneous estimation of drugs in a binary mixture without previous separation. In graphical absorption ratio method was performed by absorbance at 281.0 nm and 311.6 nm. Both the drugs MEB and PYR and its mixture follow Beer-Lambert’s law in the range of 0-30 μg/mL at all the selected wavelengths. The percent estimation of mixed drugs in laboratory mixture was done to be 100.30±0.19 and 99.32±0.78 for MEB and PYR respectively. The percent drug estimation in marketed formulation was found to be 100.30±0.34 and 101.45±1.84. The average percent recovery was found to be 100.45±0.23 and 100.98±0.60. The results of the method lies within the prescribed limit of 98-102% shows that method is free from interference from excipients.