Modifying Effects of Mosinone-A on Glycoconjugates Levels in 7, 12-Dimethyl Benz(A) Anthracene Induced Hamster Buccal Pouch Carcinogenesis

The present study was designed to investigate the modifying effects of Mosinone-A on glycoconjugates (protein bound hexose, hexosamine, total sialic acid and fucose) levels in 7,12-dimethylbenz(a) anthracene (DMBA) induced hamster buccal pouch carcinogenesis 0.5% DMBA painting (three times per week) in hamster buccal pouches for 14 weeks resulted in the formation of well developed oral squamous cell carcinoma. We observed 100% tumor formation with marked abnormalities of glycoconjugates status in tumor bearing hamsters as compared to control animals. Oral administration of Mosinone-A at a dose of 2 mg/kg body weight, to DMBA painted hamsters on alternate days for 14 weeks, reduced the tumor formation as well as protected the levels of cell surface glycoconjugates in DMBA painted hamsters. The present study thus suggests that Mosinone-A has potent chemopreventive efficacy as well as protected the abnormalities on cell surface glycoconjugates during DMBA induced hamster buccal pouch carcinogenesis.