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Synthesis and Biological Screening of Novel Aminoalkyl Substituted Azaphenothiazine
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Some novel series of alkyl substituted azaphenothiazine were synthesized by condensation of 2-chloro-1-(10H-azaphenothiazin-10yl) ethanone with various amines. The synthesized compounds were confirmed by IR, 1HNMR and Mass spectroscopy.. The bioavailabilities of the compounds were determined by Lipinski rule of 5 using customized software. All the compounds were screened for antimicrobial and sedative activity.
Keywords
Azaphenothiazine, Bioavailability, Antimicrobial Activity, Sedative Activity.
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