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Synthesis and Biological Screening of Some New Series of Aryl Thiazole Derivatives


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1 Post-Graduate Centre, Dept.of Pharmaceutical Chemistry, Karnataka College of Pharmacy, Manahalli Road, Bidar-585403, India
     

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2-Arylamino/arylidinehydrazino-4-(4-methoxyphenyl-2-yl) thiazoles were obtained by the reaction of 1-bromoacetyl-4-methoxyphenyl with various substituted arylthioureas and arylidinethiosemicarbazides in ethanol. Aminogroup of aryl thiazole have been treated with different aromatic aldehydes afford corresponding schiff bases, which on further treated with chloroacetylchloride and mercaptoacetic acid converted to corresponding azetidinones and thiazolidinones. All the compounds were characterized on basis of analytical and spectral data and these compounds were screened for invitro antimicrobial activity.

Keywords

Arylthiazole, Schiff’s Bases, Azetidinones, Thiazolidinones, Antimicrobial Activity.
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  • Synthesis and Biological Screening of Some New Series of Aryl Thiazole Derivatives

Abstract Views: 214  |  PDF Views: 0

Authors

Raga Basawaraj
Post-Graduate Centre, Dept.of Pharmaceutical Chemistry, Karnataka College of Pharmacy, Manahalli Road, Bidar-585403, India
Majid Shabbir
Post-Graduate Centre, Dept.of Pharmaceutical Chemistry, Karnataka College of Pharmacy, Manahalli Road, Bidar-585403, India

Abstract


2-Arylamino/arylidinehydrazino-4-(4-methoxyphenyl-2-yl) thiazoles were obtained by the reaction of 1-bromoacetyl-4-methoxyphenyl with various substituted arylthioureas and arylidinethiosemicarbazides in ethanol. Aminogroup of aryl thiazole have been treated with different aromatic aldehydes afford corresponding schiff bases, which on further treated with chloroacetylchloride and mercaptoacetic acid converted to corresponding azetidinones and thiazolidinones. All the compounds were characterized on basis of analytical and spectral data and these compounds were screened for invitro antimicrobial activity.

Keywords


Arylthiazole, Schiff’s Bases, Azetidinones, Thiazolidinones, Antimicrobial Activity.