Asian Journal of Research in Chemistry

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Synthesis and Antimicrobial Activity of Some Benzimidazolyl Pyrazolone Derivatives


Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
     

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A series of 2-(1H- benzimidazol-2-ylmercapto)-N-[1,5-dimethyl-2-(substituted) phenyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl] acyl amines (5a-h) have been synthesized. These structures are determined by the elemental analyses and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.

Keywords

Benzimidazole, Pyrazolone, Anti-Bacterial, Anti-Fungal.
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  • Synthesis and Antimicrobial Activity of Some Benzimidazolyl Pyrazolone Derivatives

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Authors

Ameya G. Yadav
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
Vrushali Patil
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
A. S. Bobade
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
S. V. Athlekar
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
L. S. Patil
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
Abhay Chowdhary
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India

Abstract


A series of 2-(1H- benzimidazol-2-ylmercapto)-N-[1,5-dimethyl-2-(substituted) phenyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl] acyl amines (5a-h) have been synthesized. These structures are determined by the elemental analyses and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.

Keywords


Benzimidazole, Pyrazolone, Anti-Bacterial, Anti-Fungal.