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Synthesis, Identification of Some P-Chiral Organic Phosphoramidates and Their Inhibitory Action Towards Enzymes
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Phosphoramidates (N-P) are biologically active organic compounds because they are capable of inhibiting enzyme action. A few members of this class were synthesized and checked for their anticholinesterase properties and they were found to be a good reactive phosphorylating agent to block AChE rather than BuChE in the poisoning process. The presence of chloro-substituent (either ortho- or para-) in the aryl moiety of these phosphoramidates does not show any significant contribution during toxicological study made in vitro. These phosphoramidates were characterized by FTIR, 31P NMR and GC-MS spectral studies.
Keywords
Phosphorylation, Phosphoramidates, Anticholinesterase, 31P NMR, Toxicity.
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