Asian Journal of Research in Chemistry

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Syntheses, Characterization and Biological Screening of Some Novel 1, 2, 4-Triazoles


Affiliations
1 Quality Control Laboratory, Indian Oil Corporation Limited, Panipat Refinery, Panipat, Haryana-132140, India
2 Synthetic Research Laboratory, Department of Chemistry, Tilak Dhari Post Graduate College, Veer Bahadur Singh Purvanchal University, Jaunpur-222002, Uttar Pradesh, India
     

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A series of 3-alkylthio-5-pyridyl-1, 2, 4-triazoles were prepared as possible biological active agents. All the title compounds were characterized on the basis of IR, PMR, Mass spectra and elemental analyses. All compounds carring alky substituents at position three and the 1, 2, 4- triazole moiety at position one or two showed reasonable anti-inflammatory activity.

Keywords

1, 2, 4-Triazole, 1-Picolinoylthiosemicarbazides, Alkylation, Anti-Inflammatory Activity.
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  • Syntheses, Characterization and Biological Screening of Some Novel 1, 2, 4-Triazoles

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Authors

Ram Janam Singh
Quality Control Laboratory, Indian Oil Corporation Limited, Panipat Refinery, Panipat, Haryana-132140, India
Dharmendra Kumar Singh
Synthetic Research Laboratory, Department of Chemistry, Tilak Dhari Post Graduate College, Veer Bahadur Singh Purvanchal University, Jaunpur-222002, Uttar Pradesh, India

Abstract


A series of 3-alkylthio-5-pyridyl-1, 2, 4-triazoles were prepared as possible biological active agents. All the title compounds were characterized on the basis of IR, PMR, Mass spectra and elemental analyses. All compounds carring alky substituents at position three and the 1, 2, 4- triazole moiety at position one or two showed reasonable anti-inflammatory activity.

Keywords


1, 2, 4-Triazole, 1-Picolinoylthiosemicarbazides, Alkylation, Anti-Inflammatory Activity.