Asian Journal of Research in Chemistry

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RP-HPLC Method for the Estimation of Domperidone in Bulk and Pharmaceutical Formulations


Affiliations
1 Department of Pharmaceutical Chemistry, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, A.P, India
2 Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P, India
     

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The Present work describes a simple reverse phase HPLC method for the estimation of Domperidone in bulk and pharmaceutical formulations. The estimation was carried out on Gemini, Phenomonex, C-18 (250×4.6 mm, 5 μ) column using a mobile phase consisting of potassium dihydrogen phosphate buffer-Acetonitrile-Methanol (40:30:30). The eluent was monitored at 288 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.

Keywords

HPLC Estimation, Validation, Domperidone and Pharmaceutical Formulation.
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  • RP-HPLC Method for the Estimation of Domperidone in Bulk and Pharmaceutical Formulations

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Authors

Y. Rajendraprasad
Department of Pharmaceutical Chemistry, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, A.P, India
K. K. Rajasekhar
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P, India
V. Shankarananth
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P, India
S. Bharath Kumar
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P, India
G. Dileep Kumar
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P, India
T. Sreelekha
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P, India

Abstract


The Present work describes a simple reverse phase HPLC method for the estimation of Domperidone in bulk and pharmaceutical formulations. The estimation was carried out on Gemini, Phenomonex, C-18 (250×4.6 mm, 5 μ) column using a mobile phase consisting of potassium dihydrogen phosphate buffer-Acetonitrile-Methanol (40:30:30). The eluent was monitored at 288 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.

Keywords


HPLC Estimation, Validation, Domperidone and Pharmaceutical Formulation.