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Synthesis and Biological Evaluation of 2, 5 Di-Substituted 1, 3, 4 Oxadiazoles


Affiliations
1 Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, Uttar Pradesh, India
2 Department of Pharmacy, Jamia Hamdurd, New Delhi, India
     

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Synthesis of (ethyl 2-(1H Benzo [d] [1, 2, 3] triazole-1-yl] acetate) and (2H-benzo [d] [1, 2, 3] triazole -1-yl aceto hydrazine) along with their derivatives has been done. The entire synthesized compounds were characterized by UV, IR and 1H-NMR spectroscopy. The Antimicrobial activity of the synthesized compounds was evaluated, on Streptococcus aureus and Esteria coli. The present investigation deals with the synthesized compounds possessing good antimicrobial activity.

Keywords

Esterification, Benztriazole, Antimicrobial Activity.
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  • Synthesis and Biological Evaluation of 2, 5 Di-Substituted 1, 3, 4 Oxadiazoles

Abstract Views: 236  |  PDF Views: 0

Authors

Rakesh Saini
Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, Uttar Pradesh, India
Awani K. Rai
Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, Uttar Pradesh, India
A. N. Kesari
Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, Uttar Pradesh, India
M. Shahar Yar
Department of Pharmacy, Jamia Hamdurd, New Delhi, India

Abstract


Synthesis of (ethyl 2-(1H Benzo [d] [1, 2, 3] triazole-1-yl] acetate) and (2H-benzo [d] [1, 2, 3] triazole -1-yl aceto hydrazine) along with their derivatives has been done. The entire synthesized compounds were characterized by UV, IR and 1H-NMR spectroscopy. The Antimicrobial activity of the synthesized compounds was evaluated, on Streptococcus aureus and Esteria coli. The present investigation deals with the synthesized compounds possessing good antimicrobial activity.

Keywords


Esterification, Benztriazole, Antimicrobial Activity.