Asian Journal of Research in Chemistry

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Development of UV Spectrophotometric Method of Idebenone in Bulk and Pharmaceutical Formulation


Affiliations
1 Y.B.Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Maulana Azad Education Trust, Rauza Bagh, Aurangabad (MS) 431001, India
     

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The present research work discusses the development of a UV estimation method for Idebenone. Simple, accurate, cost efficient and reproducible spectrophotometric method has been developed for the estimation of Idebenone in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement at maximum wavelength (λmax) 282nm. The percentage recovery of Idebenone ranged from 99.68 to 99.82% in pharmaceutical dosage form. Beers law was obeyed in the concentration range of 4-20μg/ml having line equation y = 0.0485x - 0.0239 with correlation coefficient of 0.9978. Results of the analysis were validated statistically and by recovery study.

Keywords

UV Spectrophotometry, Idebenone.
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  • Development of UV Spectrophotometric Method of Idebenone in Bulk and Pharmaceutical Formulation

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Authors

Amit Rathi
Y.B.Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Maulana Azad Education Trust, Rauza Bagh, Aurangabad (MS) 431001, India
Dinesh Dhamecha
Y.B.Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Maulana Azad Education Trust, Rauza Bagh, Aurangabad (MS) 431001, India
Saifee Maria
Y.B.Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Maulana Azad Education Trust, Rauza Bagh, Aurangabad (MS) 431001, India
Mohd Hassan G. Dehghan
Y.B.Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Maulana Azad Education Trust, Rauza Bagh, Aurangabad (MS) 431001, India

Abstract


The present research work discusses the development of a UV estimation method for Idebenone. Simple, accurate, cost efficient and reproducible spectrophotometric method has been developed for the estimation of Idebenone in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement at maximum wavelength (λmax) 282nm. The percentage recovery of Idebenone ranged from 99.68 to 99.82% in pharmaceutical dosage form. Beers law was obeyed in the concentration range of 4-20μg/ml having line equation y = 0.0485x - 0.0239 with correlation coefficient of 0.9978. Results of the analysis were validated statistically and by recovery study.

Keywords


UV Spectrophotometry, Idebenone.