Asian Journal of Research in Chemistry

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An efficient method for Synthesis of flavanone


Affiliations
1 Research Scholar, Department of Pharmaceutical Chemistry, A.R College of Pharmacy and G.H Patel Institute of Pharmacy, Vallabh Vidhyanagar, Anand, Gujarat, India, India
2 Professor, Department of Pharmaceutical Chemistry, A.R College of Pharmacy and G.H Patel Institute of Pharmacy, Vallabh Vidhyanagar, Anand, Gujarat, India., India
     

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The main aim of present work is to develop efficient method for synthesis of flavanone. For the synthesis of flavanone acid and based catalyzed methods were tried in which base catalyzed methods proved ineffective. No reaction was take place upon using HCl, H2SO4, glacial acetic acid and p-TSA as catalyst. In presence of methane sulphonic acid as catalyst, flavanone was formed in lower yield. Mixture of sulfuric acid and glacial acetic acid proved better catalyst than previous ones and leads to 65% yield. The reaction condition parameters effects on product yield were carried out. Ratio of sulfuric acid and glacial acetic acid in (4:1) proved highly beneficial. In methanol product yield was higher compare to other selected solvents. Solvent quantity effect on yield was also screened which proved that 50ml solvent necessary for 0.004mol of reactant. From which 90˚C temperature was highly favorable to reaction that takes minimum 6hr to complete the reaction. So, in this study we developed new efficient method for synthesis of flavanone.

Keywords

2’ hydroxyl chalcone, Flavanone, Acid catalyzed cyclisation
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  • An efficient method for Synthesis of flavanone

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Authors

Nikunj Patadiya
Research Scholar, Department of Pharmaceutical Chemistry, A.R College of Pharmacy and G.H Patel Institute of Pharmacy, Vallabh Vidhyanagar, Anand, Gujarat, India, India
Vipul Vaghela
Professor, Department of Pharmaceutical Chemistry, A.R College of Pharmacy and G.H Patel Institute of Pharmacy, Vallabh Vidhyanagar, Anand, Gujarat, India., India

Abstract


The main aim of present work is to develop efficient method for synthesis of flavanone. For the synthesis of flavanone acid and based catalyzed methods were tried in which base catalyzed methods proved ineffective. No reaction was take place upon using HCl, H2SO4, glacial acetic acid and p-TSA as catalyst. In presence of methane sulphonic acid as catalyst, flavanone was formed in lower yield. Mixture of sulfuric acid and glacial acetic acid proved better catalyst than previous ones and leads to 65% yield. The reaction condition parameters effects on product yield were carried out. Ratio of sulfuric acid and glacial acetic acid in (4:1) proved highly beneficial. In methanol product yield was higher compare to other selected solvents. Solvent quantity effect on yield was also screened which proved that 50ml solvent necessary for 0.004mol of reactant. From which 90˚C temperature was highly favorable to reaction that takes minimum 6hr to complete the reaction. So, in this study we developed new efficient method for synthesis of flavanone.

Keywords


2’ hydroxyl chalcone, Flavanone, Acid catalyzed cyclisation

References