Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Clinical Study on Serum Zinc Levels in Patients with Acne Vulgaris


Affiliations
1 Department of Biochemistry, Gandhi Medical College & Gandhi Hospital, Secunderabad, Andhra Pradesh, India
2 Department of Dermatology, Gandhi Medical College & Gandhi Hospital, Secunderabad, Andhra Pradesh, India
     

   Subscribe/Renew Journal


Objectives: To determine the serum zinc levels in young patients suffering from Acne vulgaris.
Methods: The study included 50 young female patients, aged between 13 and 19 years, suffering from Acne vulgaris (patients group) and 25 age matched healthy female attenders of patients without acne (control group). The zinc levels were measured in the serum obtained from the fasting blood of patients group and control group. Results: The serum zinc level was lower than normal in 50 out of 50 patients (100%), and in none out of 25 controls (0%). The mean zinc levels were significantly lower in patients with acne (24.4 ± 2.4μg /dl) than in controls (99.4 ± 4.5 µg/dl).
Conclusion: We conclude that zinc supplementation as an adjunctive therapy in acne patients with low serum zinc level may increase the success rate of acne treatment as zinc deficiency is one of the causes of this disease.

Keywords

Acne Vulgaris, Serum Zinc
Subscription Login to verify subscription
User
Notifications
Font Size


  • Norris D. Zinc and cutaneous inflammation. Arch Dermatol 1985; 121: 985-987.

  • Amer M,.Bahgat MR, Tosson Z, AbdelMoula MY, Amer K. Serum zinc in acne vulgaris Int J Dermatol 1982; 21: 481- 484.

  • Pohit J, Saha KC, Pal B. Zinc status of acne vulgaris patients. J Appl Nutr 1985; 37: 18-25.

  • Kaymak Y, Adisen E, Erhan M, Celik B, Gurer MA. Zinc levels in patients with acne vulgaris. J Turk Acad Dermatol 2007; 1(3): 71302a (hhtp://www.jtad.org/2007/3/jtad71302a.pdf).Nasiri S, Ghalamkarpour F, Yousefi M, Sadighha A. Serum zinc levels in Iranian patients with acne. Clinical Expl Dermatol 2009; 34: e446.

  • Saleh AOM, Anbar ZNH, Majid AY. Serum trace elements (zinc, copper and magnesium) status in Iraqi patients with acne vulgaris: case control study. Iraqi J Pharma Sci 2011; 20:44-49.

  • Shemran KA, Ewadh MJ, Al-Hamdany KJ. The relation with glutathione peroxidase, trace elements in patients with Acne vulgaris. International Journal of applied Biology and Pharmaceutical Technology (IJABPT) 2011; 2: 74-80.

  • Michaelsson G, Juhlin L, Vahlquist A. Effects of oral zinc and vitamin A in acne. Arch Dermatol 1977; 57: 357-360.

  • Orris L, Shalita A, Sibulkin D, London SJ, Gans EH. Oral zinc therapy of acne. Arch Dermatol 1978; 114: 1018-1020.

  • Verma KC, Saini As, Dhamija SK. Oral zinc sulphate therapy in acne vulgaris: a double-blind trial. Acta Derm Veneeol 1980; 60: 337-340.

  • Dreno B, Amblard P, Sirot S, Litoux P. Low doses of zinc gluconate for inflammatory acne. Acta Derm Venereol 1989; 69: 541-543.

  • Arora PN, Dhillon KS, Rajan SR, Sayal SK, Das AL. Serum zinc levels in cutaneous disprders. Miliray Journal Armed Forces India (MJAFI) 2002; 58: 304-306.

  • Sebahat T, Aziz P, Murat I, Gunfer T, Gulten E, Mevlut B, Yasin KT, Osman G. Interaction between anemia and blood levels of iron, zinc, copper, cadmium and lead in children. Indian J Pediatr. 2007; 74:827-30.

  • Bilen N. Vitamins, trace elements and essential fatty acids in skin diseases. T Klin J Dermatol 1998; 8: 116-120.

  • Katzman M, Logan AC. Acne vulgaris: nutritional factors may be influencing psychological sequelae. Med Hypotheses. 2007;69(5):1080-1084.

  • Dreno B. Topical antibacterial therapy for acne vulgaris. Drugs 2004; 64: 2389-2397.

  • Fitzherbert JC. Acne vulgaris and zinc deficiency. Med J Aust 1976; 1: 848.

  • Sansone G, Reisner RM. Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin, a possible pathogenic factor in acne .J invest Dermatol 1971:26:336-372.

  • Cunliffe WJ, Burke B, dodman B, Gould DJ. A double blinded trial of zinc sulphate/ citrate complex and tetracyclines in treatment of acne vulgaris. Br.J.Dermatol 1979, 101,321-325.

  • Cochran RJ, Tucker SB, Flanningan SA. Topical zinc therapy for acne vulgaris. Int J Dermatol 1985; 24: 188-190.

  • Schachner L, Eaglstein W, Kittles C, Mertz P. Topical erythromycin and zinc therapy for acne. J Am Acad Dermatol 1990; 22: 253-260


Abstract Views: 740

PDF Views: 2




  • Clinical Study on Serum Zinc Levels in Patients with Acne Vulgaris

Abstract Views: 740  |  PDF Views: 2

Authors

Fouqiya Butool
Department of Biochemistry, Gandhi Medical College & Gandhi Hospital, Secunderabad, Andhra Pradesh, India
C. Rekha
Department of Biochemistry, Gandhi Medical College & Gandhi Hospital, Secunderabad, Andhra Pradesh, India
A. Gnaneswar Rao
Department of Dermatology, Gandhi Medical College & Gandhi Hospital, Secunderabad, Andhra Pradesh, India

Abstract


Objectives: To determine the serum zinc levels in young patients suffering from Acne vulgaris.
Methods: The study included 50 young female patients, aged between 13 and 19 years, suffering from Acne vulgaris (patients group) and 25 age matched healthy female attenders of patients without acne (control group). The zinc levels were measured in the serum obtained from the fasting blood of patients group and control group. Results: The serum zinc level was lower than normal in 50 out of 50 patients (100%), and in none out of 25 controls (0%). The mean zinc levels were significantly lower in patients with acne (24.4 ± 2.4μg /dl) than in controls (99.4 ± 4.5 µg/dl).
Conclusion: We conclude that zinc supplementation as an adjunctive therapy in acne patients with low serum zinc level may increase the success rate of acne treatment as zinc deficiency is one of the causes of this disease.

Keywords


Acne Vulgaris, Serum Zinc

References