Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Synthesis, Anti-bacterial, Anti-fungal and Anti-inflammatory Activities of some Novel 3, 5-Diaryl-1-Aryl Pyrazoline Derivatives


Affiliations
1 Research Scholar, Bhagwant University, Ajmer and Department of Pharmaceutical Chemistry, Maratha Mandal’s College of Pharmacy, Belgaum. 590 016
2 Department of Pharmaceutical Chemistry, KLE University’s, College of Pharmacy, Rajajinagar, Bangalore-40
     

   Subscribe/Renew Journal


4-substituted acetanilide on treatment with substituted benzaldehyde affords the corresponding chalcones (C<SUB>13</SUB>-C<SUB>24</SUB>). Further treatment of chalcones with phenylhydrazine undergone cyclocondensation and gave a new series of novel 3, 5-Diaryl-1-aryl-2- pyrazoline (P13-P24). All synthesized compounds were screened for their antibacterial and antifungal activity at 75&#956;g concentration and anti-inflammatory activity at 200mg/ kg body weight. Some of the compounds have shown excellent activity

Keywords

Pyrazoline, Antibacterial, Antifungal, Anti-tubercular Activity
Subscription Login to verify subscription
User
Notifications
Font Size


  • Wiley RH. The chemistry of heterocylic chemistry, Pyrazole, Pyrazoline, Pyrazolidine, Indazoles and condensed rings. Behr LC, Fusco R, Jarboe CH. Interscience publishers; John Wiley and Sons; 1967: 3-20.

  • Rani M, Yusuf M and Khan SA. Synthesis and in-vitro antibacterial activity of [5-(furan-2-yl)-phenyl]-4, 5- carbothioamide-pyrazolines. Journal of Saudi Chemical society. 16;2012:431-436.

  • Kini S and Gandhi AM. Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents. Indian Journal of Pharmaceutical sciences. 70(1); 2008: 105-108.

  • khunt RC. et.al. Synthesis, antitubercular evaluation and 3DQSAR study of N-phenyl-3-(4-fluorophenyl)-4-substituted pyrazole derivatives. Bioorganic and Medicinal Chemistry Letters. 22; 2012: 666–678.

  • Amir M, Harishkumar and Khan SA. Synthesis and pharmacological evaluation of pyrazoline derivatives as new antiinflammatory and analgesic agents. Bioorganic and Medicinal Chemistry Letters. 18; 2008: 918–922.

  • Malhotra P, Pattan S and Nikalje AP. Microwave assisted synthesis and anti-inflammatory activity of 3, 5-diaryl substituted-2-pyrazoline. International journal of Pharmacy and pharmaceutical sciences. 2(2); 2010:21-26.

  • Cui-Yun Li. et. al. Synthesis, biological evaluation and 3DQSAR studies of novel

  • , 5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors. Bioorganic and Medicinal Chemistry. 20(12);. 2012: 3746-3755.

  • Sowmya HG and Javali C. Design, Synthesis and Evaluation of some substituted pyrazoline derivatives for their anti-convulsant activity. International Journal of Pharma World Research. 3(2); 2012.

  • Palaska E, Aytemir M, Uzbay IT and ERol D. Synthesis and antidepressant activities of some 3, 5-diphenyl-2- pyrazolines. European Journal of Medicinal chemistry. 36; 2001: 539-543.

  • Rahaman SA, Ragjendra Prasad Y, Bhuvaneswari K and Phanikumar. Synthesis and anti-histaminic activity of novel pyrazoline derivatives. International Journal of Chem Tech Research. 2(1); 2010: 16-20.

  • Hipparagi SM, Bhanushali MD, patil SA and Desai NS. Synthesis and Anti-infective studies of some novel pyrazoline derivatives. Asian J. Research Chem. 5(10); Oct 2012: 1251- 1254.

  • Arunkumar S, Ilango K, Manikandan RS and Ramalakshmi N. Synthesis and anti-inflammatory activity of some novel pyrazole derivatives of gallic acid. E-J-Chem. 6(S1):; 2009: S123-S128.

  • Anoop Singh and Rana AC. Synthesis and anticonvulsant activity of 1-[(4, 5-dihydro-5-phenyl-3(phenylamino) pyrazol-1-yl)] ethanone derivatives J. Chem. Pharm. Res. 2(1); 2010: 505-511.

  • Sahu S K, Banerjee M, Samantray A, Behra C and Azam M A. Synthesis, Analgesic, Anti-inflammatory and antimicrobial activities of some novel pyrazoline derivatives. Trop. J. Pharm. Res. 7(2); 2008: 961-968.

  • Barry AL. The Antimicrobial Susceptiblity Test: Principle and Practics, Edited by Illus leu and Febiger (Philadelphia. Pa. USA). 180; BIol. Abstr. 1976; 64: 25783.

  • Vogel GH, Drug Discovery and Evaluation- Pharmacological Assays, 2nd ed., New York; Springer Verlag; 2002: 751-71.


Abstract Views: 321

PDF Views: 2




  • Synthesis, Anti-bacterial, Anti-fungal and Anti-inflammatory Activities of some Novel 3, 5-Diaryl-1-Aryl Pyrazoline Derivatives

Abstract Views: 321  |  PDF Views: 2

Authors

M. D. Bhanushali
Research Scholar, Bhagwant University, Ajmer and Department of Pharmaceutical Chemistry, Maratha Mandal’s College of Pharmacy, Belgaum. 590 016
S. M. Hipparagi
Department of Pharmaceutical Chemistry, KLE University’s, College of Pharmacy, Rajajinagar, Bangalore-40

Abstract


4-substituted acetanilide on treatment with substituted benzaldehyde affords the corresponding chalcones (C<SUB>13</SUB>-C<SUB>24</SUB>). Further treatment of chalcones with phenylhydrazine undergone cyclocondensation and gave a new series of novel 3, 5-Diaryl-1-aryl-2- pyrazoline (P13-P24). All synthesized compounds were screened for their antibacterial and antifungal activity at 75&#956;g concentration and anti-inflammatory activity at 200mg/ kg body weight. Some of the compounds have shown excellent activity

Keywords


Pyrazoline, Antibacterial, Antifungal, Anti-tubercular Activity

References