Asian Journal of Research in Chemistry

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Spectrophotometric (Vierodt's) Method for Simultaneous Estimation of Eperisone Hydrochloride and Diclofenac Sodium in Rapisone-D SR Capsules


Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, India
2 School of Pharmacy, Taylors University, Subang Jaya, Malaysia
     

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The present method describes simple, sensitive, rapid, accurate, precise and economical Spectrophotometric method for the simultaneous determination of Diclofenac Sodium and Eperisone Hydrochloride in bulk and capsule dosage form. The method is based on the Vierodts Method (simultaneous estimation)for analysis of both the drugs using distilled water as solvent. Diclofenac sodium (DIC) has absorbance maxima at 277 nm and Eperisone hydrochloride (EPE) has absorbance maxima at 255 nm in distilled water. The linearity was obtained in the concentration range of 2- 12 μg/mL and 3-18 μg/mL for Diclofenac Sodium and Eperisone Hydrochloride, respectively. The concentrations of these drugs were determined by using vierodts equations. The mean % recovery (w/w%) was 99.3 and 100.3% for Diclofenac Sodium and Eperisone Hydrochloride, respectively. The proposed method was found to be simple and sensitive for the routine quality control application of dosage form of Diclofenac Sodium and Eperisone Hydrochloride. The results of analysis have been validated statistically according to ICH guidelines.

Keywords

Diclofenac Sodium, Eperisone Hydrochloride, Recovery, Vierodts Method, RAPISONE D SR capsules, Validation, ICH
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Abstract Views: 410

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  • Spectrophotometric (Vierodt's) Method for Simultaneous Estimation of Eperisone Hydrochloride and Diclofenac Sodium in Rapisone-D SR Capsules

Abstract Views: 410  |  PDF Views: 2

Authors

M. Alagar Raja
Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, India
Godavari Swetha
Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, India
David Banji
Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, India
S.S. Gosh
Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, India
C. Vanitha
Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, India
D. Selva Kumar
School of Pharmacy, Taylors University, Subang Jaya, Malaysia

Abstract


The present method describes simple, sensitive, rapid, accurate, precise and economical Spectrophotometric method for the simultaneous determination of Diclofenac Sodium and Eperisone Hydrochloride in bulk and capsule dosage form. The method is based on the Vierodts Method (simultaneous estimation)for analysis of both the drugs using distilled water as solvent. Diclofenac sodium (DIC) has absorbance maxima at 277 nm and Eperisone hydrochloride (EPE) has absorbance maxima at 255 nm in distilled water. The linearity was obtained in the concentration range of 2- 12 μg/mL and 3-18 μg/mL for Diclofenac Sodium and Eperisone Hydrochloride, respectively. The concentrations of these drugs were determined by using vierodts equations. The mean % recovery (w/w%) was 99.3 and 100.3% for Diclofenac Sodium and Eperisone Hydrochloride, respectively. The proposed method was found to be simple and sensitive for the routine quality control application of dosage form of Diclofenac Sodium and Eperisone Hydrochloride. The results of analysis have been validated statistically according to ICH guidelines.

Keywords


Diclofenac Sodium, Eperisone Hydrochloride, Recovery, Vierodts Method, RAPISONE D SR capsules, Validation, ICH

References