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Estimation of Lansoprazole and Naproxen by Absorption Ratio Method in Tablet Dosage Form


Affiliations
1 Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
     

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An accurate, specific and precise new Absorption Ratio method was developed for the simultaneous determination of Lansoprazole and Naproxen. The method involved Q-absorption analysis based on the measurement of absorbance at two wavelengths, i. e max of Lansoprazole (284nm) and for Naproxen was (271nm) and Iso-absorptive point of both drugs (275nm). The linearity was found to be 10-35µg/ml (r2 =0·999) for NAP and 5-30µg/ml (r 2 =0·998) for LAN. Validation was performed as ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The limit of quantification of NAP was found to be 0·15µg/ml and for LAN was 1·7µg/ml. The limit of detection of NAP was found to be 0·04µg/ml and for LAN was 0·5µg/ml. The indicating proposed spectrophotometric method was accurate and precise for estimation of NAP and LAN in tablet dosage form

Keywords

Lansoprazole, Naproxen, Iso-absorptive Point
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  • Estimation of Lansoprazole and Naproxen by Absorption Ratio Method in Tablet Dosage Form

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Authors

Nisha Choudhary
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
Inamullah
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
Sunil Singh
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
Jyoti Rai
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
Surabhi Sharma
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)

Abstract


An accurate, specific and precise new Absorption Ratio method was developed for the simultaneous determination of Lansoprazole and Naproxen. The method involved Q-absorption analysis based on the measurement of absorbance at two wavelengths, i. e max of Lansoprazole (284nm) and for Naproxen was (271nm) and Iso-absorptive point of both drugs (275nm). The linearity was found to be 10-35µg/ml (r2 =0·999) for NAP and 5-30µg/ml (r 2 =0·998) for LAN. Validation was performed as ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The limit of quantification of NAP was found to be 0·15µg/ml and for LAN was 1·7µg/ml. The limit of detection of NAP was found to be 0·04µg/ml and for LAN was 0·5µg/ml. The indicating proposed spectrophotometric method was accurate and precise for estimation of NAP and LAN in tablet dosage form

Keywords


Lansoprazole, Naproxen, Iso-absorptive Point

References