Asian Journal of Research in Chemistry

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Estimation of Lansoprazole and Naproxen by Absorption Ratio Method in Tablet Dosage Form


Affiliations
1 Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
     

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An accurate, specific and precise new Absorption Ratio method was developed for the simultaneous determination of Lansoprazole and Naproxen. The method involved Q-absorption analysis based on the measurement of absorbance at two wavelengths, i. e max of Lansoprazole (284nm) and for Naproxen was (271nm) and Iso-absorptive point of both drugs (275nm). The linearity was found to be 10-35µg/ml (r2 =0·999) for NAP and 5-30µg/ml (r 2 =0·998) for LAN. Validation was performed as ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The limit of quantification of NAP was found to be 0·15µg/ml and for LAN was 1·7µg/ml. The limit of detection of NAP was found to be 0·04µg/ml and for LAN was 0·5µg/ml. The indicating proposed spectrophotometric method was accurate and precise for estimation of NAP and LAN in tablet dosage form

Keywords

Lansoprazole, Naproxen, Iso-absorptive Point
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  • Yeniceli D, Dogrukol DAK, Tuncel M. Determination of lansoprazole in pharmaceutical capsules by flow injection analysis using UV-detection. Journal of Pharmaceutical and Biomedical Analysis. 36; 2004: 145–148.

  • Haque T, Md.Talukder MU, Laila S, Fatima K. Development And Validation of a RP-HPLC Method For Simultaneous Estimation of Naproxen and ranitidine hydrochloride. Pakistan Journal of Pharmaceutical Science. 23(4); 2010: 379-383.

  • Aanandhi VM, Thiyagarajan N, Koilraj M, Shanmugasundaram P, Sujatha M. Simultaneous Estimation of Domperidone and Lansoprazole In Capsule Formulation By HPTLC Method. Rasayan Journal of Chemistry. 1; 2009 :15-17.

  • Saudaya RB, Saraf S, et al. First order Derivative simultaneous equation curve methods for estimation of Domperidone maleate and Rabeprazlole sodium in tablet dosage form. Indian Drugs. 43(5); 2006: 388-392.

  • Oliveira CH, Abib E, et al. Lansoprazole quantification in human plasma by liquid chromatography-electrospray tandem mass spectrometry. 783: 453-459.

  • Anonymus (2009), British pharmacopoeia (BP), British Pharmacopoeial Commission, London.

  • Anonymous (2007) The United States Pharmacopeial Convention (29th Edn), Rockville, MD, pp 1485.

  • Singh S, Yadav AK, Gautam H. First order derivative spectrophotometeric determination of Telmisartan in pharmaceutical formulation. Bullatine of Pharmaceutical Research.2(2); 2012: 83-86.

  • Moustafa AAM. Spectrophotometric methods for the determination of lansoprazole and pantoprazole sodium sesquihydrate. Journal of Pharmaceutical and Biomedical Analysis. 22; 2000: 45-58.

  • Wahbi AAM, Razak AO, Mahgoub H, Azza A, Moneeb MS. Spectrophotometric determination of omeprazole, lansoprazole and pantoprazole in pharmaceutical formulations. Journal of Pharmaceutical and Biomedical Analysis. 30; 2002: 1133-1142.

  • Singh S, Inamullah, Rai J, Choudhary N, Sharma S. Stability Indicating UV-VIZ specrophotometeric method for estimation of atorvastatin calcium and fenofibrate in tablet dosage form. Bullatine of Pharmaceutical Research. 2(3); 2012: 159-166.

  • Mehta P, Sharma SC, Nikam D, Ranawat MS. Development and Validation of Related Substances Method by HPLC for Analysis of Naproxen in Naproxen Tablet Formulations. International Journal of Pharmaceutical Science and Drug Research. 4(1); 2012: 63-69.

  • Reddy SP, Sait S, Vasudevmurthy G, Vishwanath B, Prasad V, Reddy J. Stability indicating simultaneous estimation of assay method for naproxen and esomeprazole in pharmaceutical formulations by RP-HPLC. Der Pharmacia and Chemicals. 3(6); 2011: 553-564.

  • Pawar MS, Patil SB, Patil YR. Validated HPTLC Method for Simultaneous Quantitation of Domperidone Maleate and Naproxen Sodium in Bulk Drug and Formulation. Eurasian Journal of Analytical Chemistry. 5(3); 2010: 284-292.

  • Md. Mondal S, Md. Haque A, Md.Islam S, Islam A. Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Domperidone and Naproxen in Tablet Dosage Form. Journal of Applied Pharmaceutical Science. 1(7); 2011: 145-148.

  • Patel B, Dedanta Z, Dedanta R, Ramolla C, Sagar GV, Mehta RS. Simultaneous Estimation of Lansoprazole and Domperidone in Combined Dosage Form by RP-HPLC. Asian Journal of Research Chemistry. 2(2); 2009: 210-212.

  • Janardhanan VS, Manavalan R, Valliappan K. Stabilityindicating HPLC method for the simultaneous determination of pantoprazole, rabeprazole, lansoprazole and domperidone from their combination dosage forms. International Journal of Drug Development and Research. 3(4); 2011: 323-335.

  • Reddy BP, Jayaprakash M, Sivaji K, Kumar GTJ, Reddy ECS, Reddy BR. Determination of Pantoprazole Sodium and Lansoprazole In Individual Dosage Form Tablets By RP-HPLC Using Single Mobile Phase. International Journal of Applied Biomedical and Pharmaceutical Technology. 1(2); 2010: 683- 688.

  • Kumar SM, Kumar DS, Rajkumar T, Kumar EU, Geetha AS, Diwedi D. Development and validation of RP-HPLC method for the estimation of Lansoprazole in tablet dosage form. Journal of Chemicals and Pharmaceutical Research. 2(6); 2010: 291-295.

  • Singh S, Patel K, Agarwal VK, Chaturvedi S. Stability Indicating HPTLC Method for Simultaneous Determination of Valsartan and Hydrochlorothiazide in Tablets. International Journal of Pharmaceutical and Pharmac Science. 4(4); 2012: 468-471.

  • Singh S, Patel K, Agarwal VK, Chaturvedi S. Simultaneous estimation of S(-) Amlodipine Besylate Hemipentahydrate and Losartan Potassium in Combined Dosage Form by Using UVSpectroscopy. Scholar Research Library. 4(3); 2002: 897-905.

  • Singh S, Yadav AK, Gautam H. First Order Derivative Spectrophotometric Determination of Telmisartan in Pharmaceutical Formulation. Bulletin of Pharmaceutical Research. 2(2); 2012: 83-86.

  • Singh S, Dubey N, Jain DK. Simultaneous estimation of cefpodoxime proxetil and clavulate potassium combined dosage form using UV-Spectroscopy and reverse phase liquid chromatography. International Journal of Pharmaceutical and Biomedical Science. 5(1); 2011: 57-60.

  • Patel K, Singh S, Sahu P, Trivedi P. Development and validation of stability indicating assay method for naratriptan by ultra performance liquid chromatography. Scholar Research Library. 3(6); 2011: 102-107.

  • Singh S, Yadav AK, Gautam H. Simultaneous Estimation of Valsartan and Hydrochlorothiazide in Solid Dosage Form Using UV Spectroscopy. Bulletin of Pharmaceutical Research. 1(3); 2011: 10-12.

  • Singh S, Dubey N, Jain DK. Simultaneous Estimation of Atorvastatin, Clopidogrel and Aspirin in Capsule Dosage forms using UV-Spectroscopy. Asian Journal of Research and Chemistry. 3(4); 2010: 885-887.


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  • Estimation of Lansoprazole and Naproxen by Absorption Ratio Method in Tablet Dosage Form

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Authors

Nisha Choudhary
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
Inamullah
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
Sunil Singh
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
Jyoti Rai
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
Surabhi Sharma
Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)

Abstract


An accurate, specific and precise new Absorption Ratio method was developed for the simultaneous determination of Lansoprazole and Naproxen. The method involved Q-absorption analysis based on the measurement of absorbance at two wavelengths, i. e max of Lansoprazole (284nm) and for Naproxen was (271nm) and Iso-absorptive point of both drugs (275nm). The linearity was found to be 10-35µg/ml (r2 =0·999) for NAP and 5-30µg/ml (r 2 =0·998) for LAN. Validation was performed as ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The limit of quantification of NAP was found to be 0·15µg/ml and for LAN was 1·7µg/ml. The limit of detection of NAP was found to be 0·04µg/ml and for LAN was 0·5µg/ml. The indicating proposed spectrophotometric method was accurate and precise for estimation of NAP and LAN in tablet dosage form

Keywords


Lansoprazole, Naproxen, Iso-absorptive Point

References