Asian Journal of Research in Chemistry

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Synthesis, Characterization and Biological Studies of Novel Imines of Haloaryloxy Moiety


Affiliations
1 Pharmaceutical Chemistry, Arvind Gavali College of Pharmacy, Shivaji University, Satara, India
2 Dept. of Pharmaceutical Chemistry, MES College of Pharmacy, Pune University, Pune, India
     

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Haloaryloxy moiety on refluxing with chloroethyl acetate in the presence of potassium carbonate and acetone yielded ethyl halolaryloxy acetate (1), which were reacted with hydrazine hydrate to produce haloaryloxyacetyl hydrazine (2), which on treatment with aromatic aldehydes yields imines (3A-E). The novel series of compounds were elucidated on the basis of spectral studies and screened for antibacterial and antifungal studies

Keywords

Azetidinones, Imines, Hydrazine, Haloaryloxy Moiety, Antibacterial Activity, Antifungal Activity
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  • Synthesis, Characterization and Biological Studies of Novel Imines of Haloaryloxy Moiety

Abstract Views: 819  |  PDF Views: 2

Authors

Sachin Rohane
Pharmaceutical Chemistry, Arvind Gavali College of Pharmacy, Shivaji University, Satara, India
Jyoti Wagh
Dept. of Pharmaceutical Chemistry, MES College of Pharmacy, Pune University, Pune, India
Vikas Rajurkar
Pharmaceutical Chemistry, Arvind Gavali College of Pharmacy, Shivaji University, Satara, India
Shivkanya Jajoo
Pharmaceutical Chemistry, Arvind Gavali College of Pharmacy, Shivaji University, Satara, India

Abstract


Haloaryloxy moiety on refluxing with chloroethyl acetate in the presence of potassium carbonate and acetone yielded ethyl halolaryloxy acetate (1), which were reacted with hydrazine hydrate to produce haloaryloxyacetyl hydrazine (2), which on treatment with aromatic aldehydes yields imines (3A-E). The novel series of compounds were elucidated on the basis of spectral studies and screened for antibacterial and antifungal studies

Keywords


Azetidinones, Imines, Hydrazine, Haloaryloxy Moiety, Antibacterial Activity, Antifungal Activity

References