Asian Journal of Research in Chemistry

A. J. Vyas ¹, J. K. Patel ², J. R. Chavda ³, A. Bhandari ¹, N. R. Seth ⁴

Affiliations
1 Jodhpur National University, Jodhpur, IN
2 Nootan College of Pharmacy, Visnagar, Gujarat, IN
3 B.K. Mody Govt. Pharmacy College, Rajkot, IN
4 Department of Pharmaceutical Science, Saurastra University, Rajkot, IN

Abstract

Two simple, accurate, precise, sensitive and economical spectrophotometric methods; Vierodt's method and Q Absorption ratio method have been described for the simultaneous estimation of drotaverine hydrochloride (DROT) and paracetamol (PCM) in combined tablet dosage form. Absorption maxima of drotaverine hydrochloride and paracetamol in 0.05 N NaOH was found to be 230.4 nm and 257 nm respectively. Drotaverine hydrochloride and Paracetamol obey Beer's law in the concentration range 2-80 μgmL-1 (r2=0.9996) and 2-30 μgmL-1 (r2=0.9997) in 0.05 N NaOH and mean recovery for drotaverine hydrochloride and paracetamol were found to be 100.75±0.74% and 100.27±0.70%, respectively. Q absorption ratio method employs 238.8 nm as λ1 (Isobestic point) and 257 nm as λ2 (max of Paracetamol) for formation of equations. Drotaverine hydrochloride and paracetamol obey Beer's law in the concentration range 2-80 μgmL-1 (r2=0.9993) and 2-30 μgmL-1 (r2=0.9997) in 0.05 N NaOH. The mean recovery for Drotaverine hydrochloride and Paracetamol were found to be 100.47±0.10% and 100.006±0.136%. The results of two methods were validated statistically and can be successfully applied for the routine analysis of drotaverine hydrochloride and paracetamol in bulk and combined tablet dosage form.

Keywords

Drotaverine Hydrochloride, Paracetamol, Vierodt’s Method, Q Absorption Ratio Method, Spectrophotometry.

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P. K. Goyal ¹, A. Bhandari ², A. C. Rana ³, D. S. Bele ⁴

Affiliations
1 B N Girls’ College of Pharmacy, Udaipur (Raj.), IN
2 Jodhpur Pharmacy College, Jodhpur (Raj.), IN
3 Rayat Bahara College of Pharmacy, Ropad Campus, Chandigarh, IN
4 B N College of Pharmacy, Udaipur (Raj.), IN

Abstract

Five new 3-substituted -4H-1, 2, 4-triazoles derivates 4 (a-e) were synthesized by treatment of 4-alkyl diazo substituted 4H-1, 2,4-triazoles-3-thiole with different aliphatic and aromatic amines to give the titled compounds. All the synthesized derivatives were characterized by spectral (UV, IR, ¹H-NMR, MS) and elemental analysis. The in vitro antimicrobial activity of all the derivatives were evaluated against the pathogens, S. aureus, B. subtilis, P. aeruginosa, E. coli, A. niger and C. albicans. Some derivatives were found to possess very promising antimicrobial activity.

Keywords

4H-1, 2, 4-Triazole, Antimicrobial.

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