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Lakshmana Rao, A.
- A Simple and Sensitive RP-HPLC Method for Estimation of Trandolapril in Bulk and Tablet Dosage Forms
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Authors
Affiliations
1 Sri Vasavi Institute of Pharmaceutical Sciences, Tadepalligudem-534 101, A.P., IN
2 V.V. Institute of Pharmaceutical Sciences, Gudlavalleru-521 356, A.P., IN
1 Sri Vasavi Institute of Pharmaceutical Sciences, Tadepalligudem-534 101, A.P., IN
2 V.V. Institute of Pharmaceutical Sciences, Gudlavalleru-521 356, A.P., IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 9 (2011), Pagination: 1425-1427Abstract
An accurate and precise HPLC method was developed for the determination of trandolapril. Separation of the drug was achieved on a reverse phase C18 column using a mobile phase consisting of phosphate buffer and acetonitrile in the ratio of 35:65 v/v. The flow rate was 0.8 ml/min and the detection wavelength was 210 nm. The linearity was observed in the range of 20-60 μg/ml with a correlation coefficient of 0.999. The proposed method was validated for its linearity, accuracy, precision and robustness. This method can be employed for routine quality control analysis of trandolapril in tablet dosage forms.Keywords
Trandolapril, Estimation, RP-HPLC, Validation, Tablets.- Development and Validation of New HPLC Method for Estimation of Lornoxicam in Bulk and Tablet Dosage Forms
Abstract Views :199 |
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Authors
B. Raja
1,
A. Lakshmana Rao
2
Affiliations
1 Anurag Pharmacy College, Kodad-508206, A.P., IN
2 V.V. Institute of Pharmaceutical Sciences, Gudlavalleru- 521356, A.P., IN
1 Anurag Pharmacy College, Kodad-508206, A.P., IN
2 V.V. Institute of Pharmaceutical Sciences, Gudlavalleru- 521356, A.P., IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 7 (2011), Pagination: 1081-1083Abstract
An accurate and precise RP-HPLC method was developed for the determination of lornoxicam in bulk and tablet dosage forms. Separation of the drug was achieved on a reverse phase C18 column using a mobile phase consisting of phosphate buffer and methanol in the ratio of 65:35 v/v. The pH was adjusted to 3.0 with orthophosphoric acid. The flow rate was 1.5 ml/min and the detection wavelength was 289 nm. The linearity was observed in the range of 30-150 μg/ml with a correlation coefficient of 0.999. The proposed method was validated for its linearity, accuracy, precision and robustness. This method can be employed for routine quality control analysis of lornoxicam in tablet dosage forms.