Asian Journal of Research in Chemistry

Arpit Shah ¹, Dhanya B. Sen ¹, Ashim Kumar Sen ¹, Sharad Kumar ¹, Aarti Zanwar ¹, Jayesh Bodar ¹

Affiliations
1 Department of Pharmacy, Sumandeep Vidyapeeth, Pipariya, Vadodara (391760), Gujarat, IN

Abstract

A simple, accurate, precise, reproducible and economical procedure for simultaneous estimation of Fenofibrate (FENO) and Metformin hydrochloride (MET) in tablet dosage form as well as in bulk drugs have been developed using double beam UV Spectrophotometer. The method based on solving of simultaneous equation using 239 nm (λ_max of FENO) and 218 nm (λ_max of MET) as two analytical wavelengths for both drugs. The method was found to be linear in the range of 1 - 6 μgml^-1 and 3.125-18.75 μgml^-1 with mean recovery of 99.6 % and 101.82 % of fenofibrate and metformine hydrochloride, respectively. The solution of both drugs was prepared using Methanol as a solvent. The proposed method is suitable for simultaneous determination of Fenofibrate and Metformin hydrochloride in pharmaceutical dosage form.

Keywords

Fenofibrate, Metformine Hydrochloride, Methanol, U.V, Simultaneous Equation Method.

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