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Authors
Affiliations
1 VNS Institute of Pharmacy, Bhopal, (MP), IN
2 School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 11 (2011), Pagination: 1695-1700
Abstract
2-Acetoxybenzoic acid suffers from the general side effects of NSAIDs, owing to presence of free carboxylic acid group. The study was aimed to retard the adverse effects of gastrointestinal origin. 4 prodrugs of 2-Acetoxybenzoic acid were synthesized by amidation with ethyl esters of amino acids, namely, glycine, L-phenylalanine, L-glutamic acid, L-aspartic acid. Purified synthesized prodrugs were characterized by m.p., TLC, solubility, elemental analyses, UV, FTIR, NMR. Synthesized prodrugs were subjected for Antypyretic, Analgesic, Anti-inflammatory activities and Ulcerogenic index. Marked reduction of ulcerogenic index and comparable Antypyretic, Analgesic, Anti-inflammatory activities were obtained in all cases as compared to 2-Acetoxybenzoic acid.
Keywords
Prodrugs, Bioavailability, Physical Characterization, Pharmacokinetics, Pharmacodyanamics.
