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Marolia, B. P.
- Simultaneous Estimation of Cefpodoxime Proxetil and Ofloxacin in Combined Dosage Form by UV-Spectrophotometric Method
Authors
1 Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist. Surat, Gujarat-394 350, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1836-1839Abstract
Two spectroscopic methods for simultaneous estimation of cefpodoxime proxetil (CP) and ofloxacin (OFL) in combined tablet dosage form have been developed. The first method is simultaneous equations method which involves the formation of simultaneous equations at 234.90 nm (λmax of cefpodoxime) and 298 nm (λmax of ofloxacin). The second method is Q-analysis method (Q-absorbance ratio), which involves the formation of Q-absorbance equation at 271.60 nm (Iso-absorptive point) and 298 nm (λmax of ofloxacin). In this both method the linearity was evaluated over the concentration range of 2-10μg/ml for cefpodoxime and ofloxacin. The accuracy of the methods were assessed by recovery studies and was found to be 100.9±0.16% and 98.22±0.44% for simultaneous equations method and 99.5±0.133% and 98.90±0.65% for Q-absorbance ratio method for cefpodoxime and ofloxacin respectively. The proposed methods are simple, accurate, precise, rapid and cost effective. Therefore the proposed methods can be used for routine analysis of both drugs in bulk as well as in pharmaceutical formulations.Keywords
Q-Analysis Method, Iso-Absorptive Point, CP and OFL.
- Simultaneous Estimation of Cefixime and Ofloxacin by Derivative Spectroscopy Method
Authors
1 Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist, Surat, 394 350, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 3 (2011), Pagination: 415-418Abstract
Accurate, precise, rapid and economical method was developed for the estimation of Cefixime and Ofloxacin in tablet dosage form. The first order derivative spectroscopy wavelengths selected for quantitation were 312. 0 nm for Cefixime (zero cross for Ofloxacin) and 358. 2 nm for Ofloxacin (zero cross for Cefixime). In this method linearity for detector response was observed in the concentration range of 5-40 μg/ml for both Cefixime and Ofloxacin. The proposed method was successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.
Keywords
Cefixime, Ofloxacin, Derivative Spectroscopy.- Spectrophotometric Methods for Simultaneous Estimation of Thiocolchicoside and Diclofenac Sodium in Their Combined Dosage Form
Authors
1 Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi Dist, Surat 394350, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 1 (2011), Pagination: 123-127Abstract
Two simple spectrophotometric methods have been developed for simultaneous estimation of Thiocolchicoside and Diclofenac Sodium from pharmaceutical dosage form. Method I is an Absorbance correction method in which absorbance is measured at two wavelengths, 371 nm at which Diclofenac has no absorbance and 248.5 nm at which both the drugs have considerable absorbance. Method II is dual wavelength method which involves estimation of Diclofenac Sodium by plotting difference in absorbance at 248 nm and 268 nm (difference is zero for THC) against its respective concentration. THC was measured at 371nm (Diclofenac Sodium has no absorbance). Both the methods were found linear between the range of 2-16μg/ml for Thiocolchicoside and 12.5-100μg/ml for Diclofenac Sodium. The accuracy and precision were determined and found to comply with ICH guidelines. Both the methods showed good reproducibility and recovery with % RSD in the desired range. The methods were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of Thiocolchicoside and Diclofenac Sodium in their combined tablet dosage form.