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Authors
Affiliations
1 PG & Research Department of Chemistry, Islamiah College, Vaniyambadi-635751, IN
2 Department of Chemistry, Priyadarshini Engineering College, Vaniyambadi, IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 2 (2017), Pagination: 119-123
Abstract
Simple synthetic methods of 5-(5-amino-1,3,4-thiadiazol-2yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-thione (3f-j) are described. Compound 1 is converted to carbothiamide 2 by reacting compound 1 with thiosemicarbazide in catalytic amount of acetone is irradiated with help of domestic microwave oven (200W) for 2 minutes. Compound 2 is act as a key intermediate for the final compounds. The compound 2 is converted to corresponding thiadiazole 3 by treatment with conc.H2SO4 and NH3. Structural elucidation is accomplished by IR, 1H and 13CNMR, Elemental analysis and GC-Mass spectral data of the synthesized compounds. Few of these Pyrimidine derivatives have been evaluated for their possible antifungal activity. Most of the tested compounds show significant antifungal activity.
Keywords
Pyrimidine, Thiadiazole, Carbothiamide, Thiosemicarbazide, Antifungal Activity.
