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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Madurai-625107 Tamilnadu, IN
2 Department of Pharmacognosy, K. M. College of Pharmacy, Madurai-625107 Tamilnadu, IN
3 Department of Biochemistry, K. M. College of Pharmacy, Madurai-625107, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 445-447
Abstract
Anti microbial activity of Ether, Acetone Dichloromethane extract and Choloroform extracts and semi synthetic derivatives of Rimelia reticulata were tested against Gram (+) and Gram (-) bacteria strains using zone of inhibition by Agar disc diffusion method.. The bacteria used in test were Gram positive (Staphylococus aureus, Bacillus subtilis and Micrococcus luteus and Gram negative (Escherichia coli, Salmonella typhi and Pseudomonas aureginosa). Moderate antibacterial activity for Ether and Dichloromethane extract, and in Chloroform extract having more than 100% activity and Acetone extract having (90%) activity in Gram (+) organism. In Gram (-) all the extracts having moderate activity (80%). In Semi synthetic derivatives of Rimelia reticulata the Gram (+) and Gram (-) organisms are used. Among the four derivatives 2,4 di nitro hydrazine derivative has more than (100%) activity and 4 nitro phenyl hydrazine, phenyl hydrazine having moderate (80%) activity against Gram (+). In Gram (-) Hydrazine hydrate has shown more than (100% ) and Phenyl hydrazine, 4 nitro phenyl hydrazine having (90%) activity. The standard drug used in this activity is Lincomycin. Based on the current findings it can be concluded that the lichen Rimelia reticulata posses potent antibacterial activity.
Keywords
Rimelia reticulata, Antibacterial Activity, Agar Disc Diffusion Method, Crude Extracts, Semi Synthetic Derivatives.
