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Authors
Affiliations
1 East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore-560049, IN
2 Krupanidhi College of Pharmacy, Chikkabelandur, Carmelaram Post, Varthur Hobli, Bangalore-560035, IN
3 Badar Al Samaa Hospital, P.O Box-516, PC-321, Barka, OM
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 116-120
Abstract
A series of eight coumarino benzimidazoles have been synthesized from 4-fluro-3-nitrobenzoic acid with the help of a supporting polymer PEG5000 and with suitable reagents. These compounds have then been subjected to preliminary anti-inflammatory screening using formaline induce rat paw oedema model. All the synthesized compounds have activity comparable to indomethacin (20 mg/kg) by intraperitonial route.
Keywords
Coumarino Benzimidazoles, PEG5000, Anti-Inflammatory Activity.