Asian Journal of Research in Chemistry

Abstract

Novel N-phenyl-α-amino nitrone has been synthesized from formamide and one pot facile 1,3-Dipolar cycloaddition reactions of the nitrone have been studied in water at room temperature in the stereoselective synthesis of novel isoxazolidine derivatives. Significant rate acceleration, changes in stereoselectivity and high yield of these reactions are observed in water compared to organic solvents.

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Abstract

Novel C,N-diphenyl--amino nitrone has been synthesized in water and 1,3 dipolar cycloaddition reaction of the nitrone has been studied with maleimides in water. Significant rate acceleration and high yield of these reactions are observed in water compared with organic solvents. The structures of all the compounds have been established on the basis of spectral and analytical data.

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Abstract

Consecutive S_N2 reaction of -chloro nitrones are studied with isopropyl halides and the nitrones are found to have remarkable oxidizing properties for the conversion of isopropyl halides to ketones with high yields. In addition, the side product obtained can serve as efficient dipolarophile in 1,3-Dipolar cycloaddition reaction to produce spiro cycloadduct in good yield.

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