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Monago, C. C.
- Effects of Gasoline and Oxygenated Gasoline Inhalation on Lungs and Trachea in Rats
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Authors
Affiliations
1 Department of Biochemistry, University of Portharcourt, Portharcourt, NG
2 Department of Biochemistry, University Of Nigeria, Nsukka, Enugu State, NG
1 Department of Biochemistry, University of Portharcourt, Portharcourt, NG
2 Department of Biochemistry, University Of Nigeria, Nsukka, Enugu State, NG
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1872-1876Abstract
Effects of 1, 2 and 3 month - inhalation of 1216, 1824, and 2432ppm of gasoline representing GO1, GO2 and GO3 respectively were studied in rats. The OG1, OG2 and OG3 groups, represent 2432ppm of gasoline oxygenated with 1, 2 and 3% of equal volumes of methanol and isopropyl ether, respectively. Lung collapse was observed in all the groups after 3 months of exposure except in the control. In GO3 however, the severity of lung collapse was high with pneumonitis. Groups OG2 and OG3 showed mild to moderate lung collapse. This shows that oxygenation reduced the severity of lung collapse. In the trachea, there was fragmentation of muscle fibers which is more severe in GO3 groups leading to hemorrhage into the lumen of the trachea. It was generally observed from the study, that inhalation of high concentrations of gasoline for a long time like 3 months may be deleterious to health.Keywords
Gasoline, Inhalation, Lungs, Treachea.
- Diabinese and Nicotinic Acid Combination Reduced Cardiovascular Indices in Experimental Diabetes
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Method:Dithizone induced-diabetic rabbits grouped into A, B, C, D and E were treated for 72 hrs with 10 mg DB, 10 mg DB/150 mg NA, 10 mgDB/200 mg NA, 10 mg DB/250 mg NA, and 5 ml of Distil water respectively.
Result:Dithizone increased the blood glucose, urea, creatinine and creatine kinase levels. Combined therapy of DB/NA did not affect the urea level but significantly (p<0.05) reduced the levels of glucose, creatinine and creatine kinase than in single therapy.
Conclusion:Combination of diabinese and nicotinic acid could be used to reduce the high levels of glucose, creatinine and creatine kinase associated with diabetes and cardiovascular disease.
Authors
Affiliations
1 Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, NG
2 Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, NG
1 Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, NG
2 Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, NG
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 785-790Abstract
Background:Cardiovascular diseases with high levels of creatine kinase have been reported in diabetics as major killer, globally. Can single effect of diabinese(DB)- antidiabetic drug and combined effects of DB and nicotinic acid (NA)-a vitamin and an antilipidemic drug be used to manage diabetes and this associated cardiovascular disease?Method:Dithizone induced-diabetic rabbits grouped into A, B, C, D and E were treated for 72 hrs with 10 mg DB, 10 mg DB/150 mg NA, 10 mgDB/200 mg NA, 10 mg DB/250 mg NA, and 5 ml of Distil water respectively.
Result:Dithizone increased the blood glucose, urea, creatinine and creatine kinase levels. Combined therapy of DB/NA did not affect the urea level but significantly (p<0.05) reduced the levels of glucose, creatinine and creatine kinase than in single therapy.
Conclusion:Combination of diabinese and nicotinic acid could be used to reduce the high levels of glucose, creatinine and creatine kinase associated with diabetes and cardiovascular disease.
Keywords
Diabinese, Nicotinic Acid, Diabetes, Cardiovascular Disease.- Assessment of Polycyclic Aromatic Hydrocarbon Levels in Blood of Refinery Workers in Nigeria
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Petrol (gasoline) is composed of aromatic and polycyclic hydrocarbons which release carcinogenic and dangerous refinery fumes, when combusted in plants and thus health hazards. Levels of polycyclic aromatic hydrocarbon (PAH) in the serum of refinery workers (men) in Oil zone plants in Nigeria were therefore analyzed.
Purpose of the study
The study intended to find out the levels of PAH in Oil zone plant workers, with 10-27 years of exposure. This will enable us to know the exposure rate and advice the workers appropriately.
Method
Gas chromatography equipped with flame ionization detector (FID) was used. The men had worked for 8 hrs per day and 5 days per week, for 10-13, 14-19 and 20-27 years for groups A, B and C respectively. The Control group (D) comprised of 10 office workers (non-smokers) who had worked for 10-27 years.
Results
The levels of PAH (with only acenaphthene and acenaphthylene) in gasoline sample were 66.74701±0.03355 ppm/ml. PAH in the blood of workers in groups A-D were below detection limit (BDL).
Conclusion
The nature and the levels of PAH and TPH found in gasoline sample and blood of the refinery workers seem not to be deleterious to health but continuous exposure of humans to these hydrocarbons may have a long term effect.
Authors
Affiliations
1 Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, NG
1 Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, NG
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 801-804Abstract
BackgroundPetrol (gasoline) is composed of aromatic and polycyclic hydrocarbons which release carcinogenic and dangerous refinery fumes, when combusted in plants and thus health hazards. Levels of polycyclic aromatic hydrocarbon (PAH) in the serum of refinery workers (men) in Oil zone plants in Nigeria were therefore analyzed.
Purpose of the study
The study intended to find out the levels of PAH in Oil zone plant workers, with 10-27 years of exposure. This will enable us to know the exposure rate and advice the workers appropriately.
Method
Gas chromatography equipped with flame ionization detector (FID) was used. The men had worked for 8 hrs per day and 5 days per week, for 10-13, 14-19 and 20-27 years for groups A, B and C respectively. The Control group (D) comprised of 10 office workers (non-smokers) who had worked for 10-27 years.
Results
The levels of PAH (with only acenaphthene and acenaphthylene) in gasoline sample were 66.74701±0.03355 ppm/ml. PAH in the blood of workers in groups A-D were below detection limit (BDL).
Conclusion
The nature and the levels of PAH and TPH found in gasoline sample and blood of the refinery workers seem not to be deleterious to health but continuous exposure of humans to these hydrocarbons may have a long term effect.