Asian Journal of Research in Chemistry

P. K. Goyal ¹, A. Bhandari ², A. C. Rana ³, D. S. Bele ⁴

Affiliations
1 B N Girls’ College of Pharmacy, Udaipur (Raj.), IN
2 Jodhpur Pharmacy College, Jodhpur (Raj.), IN
3 Rayat Bahara College of Pharmacy, Ropad Campus, Chandigarh, IN
4 B N College of Pharmacy, Udaipur (Raj.), IN

Abstract

Five new 3-substituted -4H-1, 2, 4-triazoles derivates 4 (a-e) were synthesized by treatment of 4-alkyl diazo substituted 4H-1, 2,4-triazoles-3-thiole with different aliphatic and aromatic amines to give the titled compounds. All the synthesized derivatives were characterized by spectral (UV, IR, ¹H-NMR, MS) and elemental analysis. The in vitro antimicrobial activity of all the derivatives were evaluated against the pathogens, S. aureus, B. subtilis, P. aeruginosa, E. coli, A. niger and C. albicans. Some derivatives were found to possess very promising antimicrobial activity.

Keywords

4H-1, 2, 4-Triazole, Antimicrobial.

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D. S. Bele ¹, I. Singhvi ²

Affiliations
1 B N Girls College of Pharmacy, Udaipur (Raj.), IN
2 Pacific College of Pharmacy, Pratap Nagar, Airport Road, Udaipur (Raj.), IN

Abstract

Nine new mannich bases were synthesized by reaction between 6-substituted-2-amino-benzothiazole and 5- substituted-1-(1H-1,2,4-triazol-1-yl)-ethanone in presence of formaldehyde and conc. HCl. The synthesized compounds were characterized by IR and ¹H-NMR spectroscopy. All the synthesized compounds were screened for in vitro antimicrobial activity against the pathogens S. aureus, B. subtilis, P. aeruginosa, E. coli, A. niger and C. albicans. Few synthesized derivatives were found to exhibit good antimicrobial activity.

Keywords

2-Aminobenzothiazole, Mannich Base, 1H-1,2,4-Triazole, Antimicrobial.

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