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Authors
Affiliations
1 Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka, Hobli, Jakkur Post, Bangalore-560064, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 308-311
Abstract
Nimesulide (Biphenyl Ether) derivatives were synthesized by four steps, Step-1-Ulmaan ether synthesis, Step-2-Reduction of NO2, Step-3-Condensation reaction, Step-4-Nitration and evaluated for their anti-inflammatory and analgesic activities.
The compounds have been characterized on the basis of preliminary methods, spectral data and tested for anti-inflammatory activity and compared with standard drug as per the standard drug rat hind paw edema method by using Plethesimograph and analgesic activity by Eddies-hotplate method. Among the derivatives prepared, few showed the moderate activity and few showed decreased activity.
Keywords
Biphenyl Ether Derivatives, Phenoxy Methane Sulphonamide Derivatives, Non-Steroidal Anti-Inflammatory and Analgesic Drugs.
