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Nikhat, F.

The Phytochemicals Explored from the Roots of Syzygium Cuminni (l) Skeel Assessed for Anti-hyperglycemic Activity

Abstract Views :835 | PDF Views:2

Authors

F. Nikhat ¹, D Satyanarayana ², C.S Shastri ¹, S. Rajni ³, A.S Sheikh ³

Affiliations
1 Department of Pharmaceutical Chemistry, NGSMIPS, Deralakatte, Mangalore
2 Department of Pharmaceutical Chemistry, VIP Sciences, Rajahmundry, Andhra Pradesh
3 Department of Pharmacology, AIKTC School of Pharmacy, New Panvel, Mumbai

Source

Asian Journal of Research in Chemistry, Vol 6, No 10 (2013), Pagination: 920-925

Abstract

The entitled research finding, glimpse, incredulously led to track the emerged constituent from the ischolar_main's of Syzygium cuminii (L) skeel, on the atlas of phytochemical, chromatographic, spectroscopic data, chemically it is designated as compound (1) 3,5,7-trihydroxy-2-(3,4,5trihydroxypheny)-4H-1-benzopyrone-4-one.gentobios, (ScReX-5), compound (2) 3,5,7-trihydroxy-2-(3,4,5-trihydroxy phenyl)-4H-1-benzopyrone-4-one,5-glycosid (ScReX-6b). Alt on the assessment of anti-hyperglycemic activity in alloxan induced diabetic rat model, the adopted methodology manifest; legendary results to maintain, the increased blood glucose level to normal. Moreover the restoration of decreased body weight to normal level was also observed.

Keywords

Syzygium Cuminii (l) Antidiabetic, Anti-hyperglycemic, Spectroscopic

Full Text

References

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Mahapatra, P.K., Pal, M., Chaudhuri, A.K.N., Chakraborty, D., Basu, A., 1985. Preliminary studies on glycaemic effects of Syzigium cumini seeds. IRCS Medical Science—Biochemistry 13 (7), 631–632.

Nikhat F, D Satynarayanaa and Arun B Joshi. Phytochemical and Pharmacological Investigation of Roots of Syzygium Cuminii (L) Skeel . Asian J. Research Chem. July-Sept. 2008, 1(1):22-25

Rastogi, R.M.; Mehrotra, B.N. Compendium of Indian Medicinal Plants. Central Drug Research Institute: Lucknow, India, 1990; vol. 1, pp. 388-389.

Samba-Murthy, A.V.S.S., Subrahmanyam, N.S., 1989. Fruits. In: Johry, V.S. (Ed.), A Text Book of Economic Botany. Wiley, New Delhi, India, p. 629.

Warrier, P.K.; Nambiar, V.P.K.; Ramankutty, C. Indian Medicinal Plants. Orient Longman Ltd. Hyderabad, India, 1996; vol. 5, pp. 225-228.

Analytical Parameters of Isolated Constituents of Root’s of Syzygium cuminii (L) skeel

Synthesis, Characterization and Anti-Microbial Evaluation of Substituted Isoxazole Derivatives

Abstract Views :190 | PDF Views:0

Authors

A. Moid ¹, F. Nikhat ¹, M. G. Purohit ¹, A. Thouheed ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy, Gulbarga - 585102, IN

Source

Asian Journal of Research in Chemistry, Vol 4, No 7 (2011), Pagination: 1158-1160

Abstract

The prevalence of isoxazole cores in natural and biologically active molecules has stimulated the need for elegant and efficient ways to make these heterocycles as lead. A systematic investigation of this class of heterocycle revealed that isoxazole containing pharmacoactive agent's possess analgesic, anti-inflammatory and antimicrobial activities. 4-(5'- substituted-aryl-4,5'-dihydro-isoxazole-3'-yl-amino) phenols possessing potent biological activities. N-(4'- hydroxyphenyl) acetamide (2) was synthesized by the condensation of p-amino phenol (1) with acetyl chloride by refluxing in alkaline medium for 20 minutes. 3-substituted N-(4'-hydroxyphenyl) propanamides (3a-g) were prepared by the reaction of N-(4-hydroxy phenyl) acetamide with various substituted aryl aldehydes by refluxing for 6 hours in ethanol. The resultant compounds on refluxing for 6 hours with hydroxylamine hydrochloride gave the title compounds 4-(5'-substituted-aryl-4', 5'-dihydro-isoxazole-3'-yl-amino) phenols (4a-g). The synthesized derivatives have been characterized by FT-IR, 1HNMR and Mass spectral analysis. All the derivatives synthesized were screened for their anti-bacterial and antifungal activities at the concentration level of 100 μg/ml by cup-plate method. Some of the compounds such as 4a, 4b, 4c, 4d and 4f have shown significant antibacterial and antifungal activity when compared to standard drugs Ciprofloxacin (antibacterial activity) and Clotrimazole (antifungal activity). The results obtained indicate that, when the phenyl group at 5^th position of isoxazole nucleus contains the substituents as electron withdrawing atoms/groups particularly at ortho and meta positions could be a decisive factor for the compounds to have the increased potency over the other positions.

Keywords

Isoxazoles Derivatives, Anti-Bacterial Activity, Anti-Fungal Activity.

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The Compact Phytochemistry Report on Syzygium cuminii(L) Skeel

Isolation, Charectrisation and Screening of Antioxidant Activity of the Roots of Syzygiumcuminii (L) Skeel

Phytochemical and Pharmacological Investigation of Roots of Syzygium cuminii (L) Skeel

Abstract Views :163 | PDF Views:0

Authors

F. Nikhat ¹, D. Satynarayanaa ¹, Arun B. Joshia ¹

Affiliations
1 Department of Pharm. Chem., Nitte Gulabi, Shetty Memorial Institute of Pharm. Sciences, Mangalore-574160, Karnataka, IN

Source

Asian Journal of Research in Chemistry, Vol 1, No 1 (2008), Pagination: 22-25

Abstract

The ischolar_mains of syzygium cuminii (L) skeel was collected in Gulbarga district Karnataka. Dried and subjected for extraction with petroleum ether ,chloroform the residue obtained after the evaporation of chloroform was taken for further study to isolate six chemical constituent present in it (ScRex-3, ScRex-4, ScRex-5, ScRex-6a, ScRex-6b, ScRex-2,) this constituent were subjected for structural elucidation by physical measurement and phyto-chemical study. The pharmacological study describe is restricted only to the antidiabetic activity of chloroform extract the result obtained is compared with standard used for antidiabetic study for the measurement of glucose level in blood. The further study is in progress to isolate the above component in higher quantity and screen them for antidiabetic properties.

Keywords

Syzygium cuminii, Myrtaceae, Chloroform Extract, Antidiabetic.

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