A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Vidyasagar, G.
- Preparation and Evaluation of Inclusion Complexes Using Cyclodextrins and Its Derivatives
Authors
1 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, IN
2 Bhagwan College of Pharmacy, Aurangabad, IN
3 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 5, No 1 (2012), Pagination: 131-135Abstract
Domperidone is a widely used antiemetic, poorly water soluble drug, erratically absorbed in stomach and possess several dissolution related problems thus it has poor bioavailability. Solubility of a drug plays a very important role in dissolution and hence absorption of drug which ultimately affects its bioavailability. Hence, by considering the facts related to drug, attempts have been made to formulate inclusion complexes using various derivative of cyclodextrins.
Inclusion complexes were prepared using methylated betacyclodextrin and hydroxy propyl betacyclodextrin in 1:1 and 1:2 molar ratios. Kneading, ultrasonification and physical mixture method were used for preparation of inclusion complexes. The solubility and dissolution results revealed that there was an increase in solubility and dissolution of all inclusion complexes as compared to pure drug but was highest in case of methylated betacyclodextrin in 1:1molar ratio using ultrasonification method(USM1) and with hydroxypropyl betacyclodextrin in 1:2 molar ratio using ultrasonification method(USHP2).
Keywords
Cyclodextrins , Inclusion Complex.
- Multi-Component Reaction and their Application in Drug Discovery
Authors
1 Veerayatan Institute of Pharmacy, Mandvi-Kutch, Gujarat, IN
2 R.B. Patel Mahila Pharmacy College, Atkot, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1818-1824Abstract
Multicomponent reactions (MCRs) provide a powerful tool towards the one-pot synthesis of diverse and complex compounds on the one hand and small and 'drug-like' heterocycles on the other hand. No other single synthesis technology enables chemists to search such large chemical spaces as provided by MCRs. This review describes various three component and four component reaction example and recent advances in the application of isocyanide-based multicomponent reactions (IMCRs) in drug discovery.Keywords
Multicomponent Reaction, Three Component Reaction, Four Component Reaction, Application, Isocyanide Based Reaction.- Mechanochemistry-A New Era in Synthesis for Pharmaceutical Researchers
Authors
1 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
2 Dean (Pharmacy Department) Kutch University, Bhuj, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 6 (2011), Pagination: 851-856Abstract
Mechanochemistry is the emerging branch of chemical science which obeys the principles of green chemistry. The power of mechanical friction is the source of energy for completion of reaction. Basically it was classified in the metallurgical sciences but due to its compatibility and ease of practice it will readily adopted in science of chemical synthesis. Organics as well as inorganic substances can be subjected to modification by virtue of it. It appears to be a science with a sound theoretical foundation which exhibits a wide range of potential application. The simplest and best example is of KBr plates; it will induced by milling and pressing of analyte with KBr to form a disk for IR spectroscopy, resulting in a change of the spectrum of the analyte. So it was worthwhile to adopt this technique in synthesis of pharmaceuticals.Keywords
Green Chemistry, Mechanochemistry, Mechanical Friction, Synthesis.- Preparation and Evaluation of Anti-Inflammatory Transdermal Drug Delivery System
Authors
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur- 425201, IN
2 B.N.B.Swaminarayan College of Pharmacy, Vapi, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
5 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 5 (2011), Pagination: 791-794Abstract
An abundance of the anti-inflammatory drugs are available for use in current medicine which have an established use in the treatment of arthritis and other painful conditions, amongst them one of the novel drug is Aceclofenac. Gels are an excellent formulation for several routes of administration such as oral, topical, nasal, vaginal, and rectal. Gel can be clear formulations when all of the particles completely dissolve in the dispersing medium. But this doesn't occur in all gels, and some are therefore turbid. This need has emphasized the importance of developing a topical dosage form of such drugs.
Aceclofenac is novel non steroidal anti-inflammatory drug which have proven its effectiveness in many of painful diseased conditions like osteoarthritis, rheumatoid arthritis, spondylitis etc. Like other NSAIDs it is also associated with adverse effects, majority of them are of gastrointestinal system (dyspepsia, abdominal pain, nausea and diarrhea). Present study was undertaken to develop an effective and stable topical formulations of Aceclofenac gel.
Keywords
TDDS, Aceclofenac.- Sonochemical Synthesis of 2, 3-Diphenylquinoxaline Using Different Catalysts, a Green Chemistry Approach
Authors
1 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
2 Dean (Pharmacy Department) Kutch University, Bhuj, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 6 (2011), Pagination: 887-889Abstract
A simple, highly efficient and green procedure for the condensation of aryl and alkyl 1, 2-diamines with α-diketones in the presence of different catalyst at room temperature is described. And the recycled catalyst was used for the next run under identical reaction conditions. Using this method, quinoxaline derivatives as biologically interesting compounds are produced in high to excellent yields and short reaction times. Present synthesis complies with principle of Green chemistry. As part of current studies, we here in report efficient practical technique of sonication reaction (sonosynthesis). The overall progress of the reaction was monitored by TLC and characterized by IR and NMR. Compared with traditional methods, these methods are more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. The synthesized 2, 3-diphenyle quinoxaline was confirmed by physical constant and spectroscopic studies. Low cost, reuse of worn catalyst and maximum efficiency are some advantages of this synthesis. Compared with traditional method, this method is more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. From these features present methods can be correlated for safer and efficient synthesis of other products.Keywords
Sonochemistry, Quinoxaline, Catalyst.- Estimation of Rosiglitazone in Bulk and Tablet Dosage Forms by HPTLC Method
Authors
1 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi-370460, IN
2 Babaria Institute of Pharmacy, Vadodara-391240, IN
3 Jiladia Hospital, New Anjar, Anjar (Kutch)-370110, IN