Asian Journal of Research in Chemistry

H. G. Akkamma ¹, B. S. Vikram ¹, T. Srinivas Rao ¹, D. Baggiya Selvi ¹

Affiliations
1 Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka, Hobli, Jakkur Post, Bangalore-560064, IN

Abstract

Nimesulide (Biphenyl Ether) derivatives were synthesized by four steps, Step-1-Ulmaan ether synthesis, Step-2-Reduction of NO₂, Step-3-Condensation reaction, Step-4-Nitration and evaluated for their anti-inflammatory and analgesic activities.
The compounds have been characterized on the basis of preliminary methods, spectral data and tested for anti-inflammatory activity and compared with standard drug as per the standard drug rat hind paw edema method by using Plethesimograph and analgesic activity by Eddies-hotplate method. Among the derivatives prepared, few showed the moderate activity and few showed decreased activity.

Keywords

Biphenyl Ether Derivatives, Phenoxy Methane Sulphonamide Derivatives, Non-Steroidal Anti-Inflammatory and Analgesic Drugs.

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T. Srinivas Rao ¹, H. G. Akkamma ¹, B. S. Vikram ¹

Affiliations
1 Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post, Bangalore-560064, IN

Abstract

The results have shown that the Aryloxy-4-thiazolidinone derivatives are found to be effective anti-bacterial agents. The synthesized compounds were elucidated by spectral data. By analysis of IR, NMR and MASS spectral data the compounds reveals the successful information of Aryloxy-4-thiazolidinone derivatives. The synthesized compounds were screened for their anti-bacterial activities by using standard as ampicilin and are found to be effective chemotherapeutic agent. The synthesis of Thiazolidinones by the described methods resulted in the products with good yield.

Keywords

Aryl Oxy Ethyl Acetate, Schiff Bases, Aryl Oxy Acethydrazide, Ethyl Chloroacetate, Phenol.

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