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Seshagiri Rao, J. V. L. N.
- A Validated Reverse Phase HPLC Method for the Simultaneous Estimation of Atorvastatin Calcium and Ezetimibe in Pharmaceutical Dosage Forms
Abstract Views :174 |
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Authors
Affiliations
1 Hindu College of Pharmacy, Amaravathi Road, Guntur-522002 (Andhra Pradesh), IN
2 Department of Environmental Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, IN
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, IN
1 Hindu College of Pharmacy, Amaravathi Road, Guntur-522002 (Andhra Pradesh), IN
2 Department of Environmental Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, IN
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 225-228Abstract
A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Atorvastatin calcium and Ezetimibe in pharmaceutical dosage forms. The mobile phase consisted of Acetonitrile: buffer (0.1% v/v ortho phosphoric acid, PH-6) in the ratio 60:40 delivered at a flow rate of 1 ml/min and wavelength of detection at 232 nm. The retention times of Atorvastatin calcium and Ezetimibe were 3.7 min and 6.1 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for determination of these drugs in combined dosage forms.Keywords
Atorvastatin Calcium, Ezetimibe, RP-HPLC.- The Estimation of Irinotecan HCl in Parenterals by RP-HPLC
Abstract Views :177 |
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Authors
V. Kiran Kumar
1,
N. Appala Raju
2,
Namratha Rani
2,
J. V. L. N. Seshagiri Rao
3,
T. Satyanarayana
2
Affiliations
1 Dept. of Pharma. Chem., Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Karimnagar-505527, A.P., IN
2 Dept. of Pharma. Chem., Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road#3, Banjara Hills, Hyderabad-500034, IN
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P., IN
1 Dept. of Pharma. Chem., Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Karimnagar-505527, A.P., IN
2 Dept. of Pharma. Chem., Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road#3, Banjara Hills, Hyderabad-500034, IN
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P., IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 54-56Abstract
A simple, precise, rapid and accurate reverse phase HPLC method developed for the estimation of Irinotecan HCl in tablet dosage form. A X-Terra RP C18, 250×4.6 mm i.d, 5 μm partical size, with mobile phase consisting of Methanol and 0.01 M Ammonium Acetate containing 0.1% formic acid and methanol in the ratio of 50:50 v/v was used. The flow rate was 1 ml/min and the effluents were monitored at 250 nm. The retention time was 4.69 min. The detector response was linear in the concentration of 120-360 mcg/ml. The respective linear regression equation being Y=166582.24x+86439.5. The limit of detection and limit of quantification was 0.06 and 0.18 mcg/ml respectively. The percentage assay of Irinotecan HCl was 99.09%. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Irinotecan HCl in bulk drug and in its pharmaceutical dosage form.Keywords
Irinotecan HCl, RP-HPLC, Estimation, and Tablets.- The Estimation of Paclitaxel in Parenterals by RP-HPLC
Abstract Views :155 |
PDF Views:0
Authors
V. Kiran Kumar
1,
N. Appala Raju
2,
Namratha Rani
2,
J. V. L. N. Seshagiri Rao
3,
T. Satyanarayana
2
Affiliations
1 Dept. of Pharma. Chem., Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Karimnagar-505527, AP, IN
2 Dept. of Pharma. Chem., Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road 3, Banjara Hills, Hyderabad-500034, IN
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, AP, IN
1 Dept. of Pharma. Chem., Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Karimnagar-505527, AP, IN
2 Dept. of Pharma. Chem., Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road 3, Banjara Hills, Hyderabad-500034, IN
3 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, AP, IN