Asian Journal of Research in Chemistry

R. K. Nanda ¹, J. Gaikwad ¹, A. Prakash ¹, V. K. Ghosh ¹, D. H. Nagore ¹

Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, IN

Abstract

Two accurate and precise methods were developed for the estimation of Cefixime and Erdosteine in its pharmaceutical dosage form. First method is area under the curve method; the areas under the curve in the range of 294.5-284.5 nm (for CEF) and 240.0-230.0 nm (for ERD) were selected for the analysis. Second method is first order derivative spectroscopy by solving simultaneous equation, 309.0 nm (for CEF) and 227.5 nm (for ERD) were selected for the analysis. In both the methods linearity for detector response was observed in the concentration range of 10-50 μg/ml for both Cefixime and Erdosteine. The proposed methods were successfully applied for the simultaneous determination of both drugs in its pharmaceutical preparation. The results of the analysis have been validated statistically and by recovery studies.

Keywords

Cefixime, Erdosteine, Area Under the Curve Method, Derivative Spectroscopy.

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R. K. Nanda ¹, J. Gaikwad ¹, A. Prakash ¹

Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, IN

Abstract

Three simple, precise and economical UV methods have been developed for the estimation of Tamsulosin in pharmaceutical dosage form. Tamsulosin has the absorbance maxima at 281.0 nm (Method A), and in the first order derivative spectra, showed sharp peak at 234.5 nm (Method B). Method C applied was area under curve (AUC), in the wavelength range of 286.0-276.0 nm. Linearity for detector response was observed in the concentration range of 5-25 μg/ml for all three methods. The proposed methods were successfully applied for the simultaneous determination of Tamsulosin in commercial pharmaceutical preparation. The results of the capsule analysis were validated statistically and by recovery studies. It was found to be satisfactory.

Keywords

Tamsulosin, Absorbance Maxima, Derivative Spectroscopy, Area Under Curve.

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