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Saraswathi, K.
- Adaptation of Color Reactions for Spectrophotometric Determination of Mosapride Citrate in Formulations
Authors
1 Department of Chemistry, R.V.R. & J.C. College of Engineering, Guntur, A.P., IN
2 Department of Chemistry, S.V. University, Tirupathi, A.P., IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 6 (2011), Pagination: 896-897Abstract
Three new, simple and sensitive visible spectrophotometric methods (A, B and C) have been developed for the determination of Mosapride Citrate in bulk drug and pharmaceutical formulations. Method A is based on the condensation of Mosapride Citrate with salicylaldehyde to form schiff's base, which was a yellow colored chromogen exhibiting λmax at 410 nm. Method B is based on the formation of pink colored chromogen obtained when Mosapride Citrate was diazotized with nitrous acid followed by coupling with α-naphthyl amine, exhibiting λmax at 520 nm. Method C is based on the oxidation of Mosapride Citrate with Fe (III) and the estimation of Fe (II) produced after chelation with potassium ferricyanide, which was a bluish green colored chromogen, exhibiting λmax at 770 nm. The Beer's law was obeyed in the concentration range of 4-20, 10-40 and 4-24 μg/ml for methods A, B and C respectively. The results of the proposed methods have been validated statistically and by recovery methods.
Keywords
Spectrophotometry, Salicylaldehyde, α-Naphthyl Amine, Potassium Ferricyanide.
- Application of Oxidants to the Spectrophotometric Determination of Cephalosporins (Cefditoren Pivoxil and Cefdinir) In Formulations
Authors
1 Department of Chemistry, R.V.R. and J.C. College of Engineering, Guntur, A.P., IN
2 Department of Chemistry, S.V. University, Tirupathi, A.P., IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 2 (2011), Pagination: 270-271Abstract
Three new spectrophotometric methods (A, B and C) for the determination of Cephalosporins (Cefditoren Pivoxil and Cefdinir) have been proposed. These methods are based on the oxidation of the drug with Fe (III) and the estimation of Fe (II) produced after chelation with either 1,10- Phenanthroline or 2,2’-Bipyridyl or Potassium Ferricyanide at 510, 525, 730 nm (for Cefditoren Pivoxil) and at 512, 510, 700 nm (for Cefdinir). The Beer’s law was obeyed in the concentration range of 4-20, 4-20, 2-10 μg/ml (for Cefditoren Pivoxil) and 2-8, 8-24, 4-12μg/ml (for Cefdinir) for methods A, B and C respectively. Thus results of the proposed methods were validated statistically and applied successfully to the determination of Cefditoren Pivoxil and Cefdinir in bulk and its pharmaceutical formulations without any interference from excipients.