Asian Journal of Research in Chemistry

Kalpana Divekar ¹, Jani Hardik ¹, S. Brahmani Priyadarshini ¹

Affiliations
1 Department of Pharmaceutical Chemistry and Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore – 560078, Karnataka State, IN

Abstract

Pyrimidines are the class of heterocyclic compounds of pharmaceutical importance. The compounds having pyrimidine ring moiety are associated with fungicidal, anti-inflammatory, anti-HIV, antioxidant and anti-tumor activities.

In the present study, an attempt was made to synthesize and characterize substituted pyrimidine derivatives and they were screened for antimicrobial and antioxidant activities by Filter disc method and DPPH method, respectively.

Keywords

Pyrimidine, Antimicrobial Activity, Antioxidant Activity, Filter Disc Method.

Full Text

     

V. Murugan ¹, S. Revathi ², K. Sumathi ³, K. M. Geetha ¹, Kalpana Divekar ¹

Affiliations
1 Dayanandasagar College of Pharmacy, Bangalore, Karnataka, IN
2 JSS College of Pharmacy, Ooty, Tamilnadu, IN
3 JKKMMRS College of Pharmacy, Kumarapalayam, Tamilnadu, IN

Abstract

A series of 1-[Bis-N, N-(2-Chloroethyl) aminoacetyl]-3,5-disubstituted-1,2 pyrazolines have been synthesized by the treatment of 1-[Bis-N, N-(2-hydroxyethyl) aminoacetyl]-3,5-disubstituted-1,2-pyrazolines with Phosphorous oxychloride, the starting compound pyrazoline was synthesized from various aldehydes and acetophenones. The synthesized compounds have been characterized by their analytical, IR, 1H-NMR and mass spectral data. The titled compounds were investigated for their possible anticancer activities by in vitro and in vivo methods. These compounds were found to exhibit a moderate anticancer activity when compared to cyclophosphamide employed as a reference drug for comparison.

Keywords

Synthesis, Pyrazoline Derivatives, Anticancer Activity, Dalton’s Lymphoma Ascite (DLA) Cell Line.

Full Text