Asian Journal of Research in Chemistry

Parmesh Kumar Dwivedi ¹, Kishu Tripathi ², Mamta Mishra ³

Affiliations
1 Amity University, Lucknow, IN
2 Surya College of Pharmacy, Lucknow, IN
3 State Public Analytical Laboratory(FDA), Lucknow, IN

Abstract

Aminopyrimidine and its derivatives have a great biological importance. In last decades a number of compounds have been synthesized having aminopyrimidine moiety either fused with other ring system or its derivatives. These synthesized compounds show a lot of biological activity like anticancer, antimicrobial, antimalarial, antiviral and various other biological activities having importance in the treatment of diseases. Many reviews on pyrimidine are available but there is no collective information about aminopyrimidines for recent years. The purpose of present review is to provide exhaustive information about the aminopyrimidine as new target of drug synthesis.

Keywords

Aminopyrimidine.

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Parmesh Kumar Dwivedi ¹, Kishu Tripathi ², Mamta Mishra ³

Affiliations
1 Amity University, Lucknow, IN
2 Surya College of Pharmacy, Lucknow, IN
3 State Public Analytical Laboratory (FDA), Lucknow, IN

Abstract

Aminopyrimidine and its derivatives have a great biological importance. In last decades a number of compounds have been synthesized having aminopyrimidine moiety either fused with other ring system or its derivatives. These synthesized compounds show a lot of biological activity like anticancer, antimicrobial, antimalarial, antiviral and various other biological activities having importance in the treatment of diseases. Many reviews on pyrimidine are available but there is no collective information about aminopyrimidines for recent years. The purpose of present review is to provide exhaustive information about the aminopyrimidine as new target of drug synthesis.

Keywords

Aminopyrimidine.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow (UP), IN

Abstract

Garlic, Allium sativum is among the oldest of all cultivated plants. It has been used as a medicinal agent for thousands of years. It is a remarkable plant, which has multiple beneficial effects such as antimicrobial, antithrombotic, hypolipidemic, antiarthritic, hypoglycemic and antitumoractivity, hypocholesterolaemic, antioxidant, pesticidal, antidepressant, neuroprotective, artery and heart protector, hair re-growth inducer, immune booster etc.

Keywords

Garlic, Allium sativum.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow (UP), IN

Abstract

Herbal abortifacients are among the oldest herbal medicines, found in every indigenous pharmacopeia including Black Cohosh, Blue Cohosh, Gossypium, Primrose (Oenotherahookeri), Parsley (Petroselinum crispum), Penny Royal (Mentha Pulegium), Pineapple, Tansy (Tanacetum vulgare), Daucus carota, Vitamin C etc.

Keywords

Herbal Abortifacients, Black Cohosh, Blue Cohosh, Penny Royal.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow, IN

Abstract

Garlic [Allium sativum] is among the oldest of all cultivated plants. It has been used as a medicinal agent for thousands of years. It is a remarkable plant, which has multiple beneficial effects such as antimicrobial, antithrombotic, hypolipidemic, antiarthritic, hypoglycemic and antitumor activity etc.

Keywords

Garlic, Allium.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow, IN

Abstract

Metallopharmaceuticals used as anticancer agents, metal-mediated antibiotics, antibacterials, antivirals, antiparasitics, antiarthritics, andradiosensitizing agents appear in therapeutic medicinal inorganic chemistry.

Keywords

Metallopharmaceuticals, Metallodrugs.

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Alka Verma ¹, Bhupesh Verma ¹, Sunil Kumar Prajapati ², Kishu Tripathi ³

Affiliations
1 Saroj Institute of Technology and Management, Lucknow (UP), IN
2 Department of Pharmacy, Bundelkhand University, Jhansi (UP), IN
3 Surya College of Pharmacy, Lucknow (UP), IN

Abstract

The development of prodrugs promises to be very effective method for treatment of diseases in future. This approach has several advantages over conventional drug administration. Prodrugs design to maximize the amount of an active drug reaching its target through changing the physicochemical, biopharmaceutical or pharmacokinetic properties of drugs. It also includes characteristics development and classification, effect of prodrug on solubility, permeability and targeted challenge.

Keywords

Prodrug, Delivery System.

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Kishu Tripathi ¹, Shobha Kulshreshtha ²

Affiliations
1 Surya College of Pharmacy, Lucknow, IN
2 Department of Pharmacology, SN Medical College, Agra, IN

Abstract

Inhibiting 11HSD2;mediate cortisol-dependent nuclear translocation and transcriptional activation of MR and are responsible at least for a part of the sodium retention and potassium excretion observed in patients with biliary obstruction;dose-dependent scratching of the injected site with the forepaws and hindpaws. Up to 100 μg of sodium deoxycholic acid, deoxycholic acid induced intestinal secretion in part by lowering mucosal permeability; DCA decreased adhesion of HCA-7 cells to the substratum and induced dephosphorylation of FAK at Tyrosine-576/577 (Tyr-576/577) and Tyr-925; inhibition of Clostridium botulinum, hyperproliferation of colonic crypt cells with an expansion of the proliferative zone,which is regarded as a biomarker of increased cancer risk; significantly increase tyrosine phosphorylation of catenin, induce urokinase-type plasminogen activator, uPAR, and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness ,major impact on apoptotic mechanisms in colonic cells and this may be contributing to its effect as a tumor promoter.

Keywords

Deoxycholic Acid.

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